MBIMPH
Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =9nM). Displays high selectivity over all other HDACs (IC50=0.1-12µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (Prod. No. AG-CR1-3900). HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
| Catalog Number | AG-CR1-3907-M001 |
| Alternative Name(s) | N-Hydroxy-4-((2-methyl-1H-benzo[d]imidazol-1-yl)methyl)benzamide |
| Research Area | Biochemicals, Cancer, Inflammation, Neurodegenerative Disease |
| Molecular Formula | C16H15N3O2 |
| CAS# | 1392835-53-8 |
| Purity | >98% |
| Inchi | InChI=1S/C16H15N3O2/c1-11-17-14-4-2-3-5-15(14)19(11)10-12-6-8-13(9-7-12)16(20)18-21/h2-9,21H,10H2,1H3,(H,18,20) |
| Inchi Key | SGZCUGGIJNIVPP-UHFFFAOYSA-N |
| SMILES | CC1=NC2=C(C=CC=C2)N1CC1=CC=C(C=C1)C(=O)NO |
| Size | 1 mg |
| Supplier Page | http://www.adipogen.com/ag-cr1-3907/mbimph.html |