Z-VRPR-FMK
Selective cell permeable and irreversible MALT1 inhibitor. Inhibits NF-kappaB-dependent gene expression and affects the growth, proliferation and survival of activated B cell-like diffuse large B cell lymphomas (ABC-DLBCL) and germinal center B cell like diffuse large B cell lymphoma (GCB-DLBCL) cell lines. Shown to inhibit the autoprocessing activity of MCA2ac (calcium dependent) in Trypanosoma brucei.
| Catalog Number | AG-CP3-0008-M001 |
| Alternative Name(s) | Z-Val-Arg-Pro-DL-Arg-FMK . TFA |
| Research Area | Apoptosis, Autophagy, Biochemicals, Cancer, Cell Death, Inflammasomes, Inflammation, Necrosis, Neurodegenerative Disease |
| Molecular Formula | C31H49FN10O6 . C2HF3O2 |
| CAS# | 1381885-28-4 (free base) |
| Purity | >90% |
| Inchi | InChI=1S/C31H49FN10O6/c1-19(2)25(41-31(47)48-18-20-9-4-3-5-10-20)27(45)40-22(12-7-15-38-30(35)36)28(46)42-16-8-13-23(42)26(44)39-21(24(43)17-32)11-6-14-37-29(33)34/h3-5,9-10,19,21-23,25H,6-8,11-18H2,1-2H3,(H,39,44)(H,40,45)(H,41,47)(H4,33,34,37)(H4,35,36,38)/t21?,22-,23-,25-/m0/s1 |
| Inchi Key | DYQKGOBRZWMAHV-YTJMMMLMSA-N |
| SMILES | OC(=O)C(F)(F)F.CC(C)[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C(=O)CF |
| Size | 1 mg |
| Supplier Page | http://www.adipogen.com/ag-cp3-0008/z-vrpr-fmk.html |