BQ-123 . sodium salt

Potent and selective endothelin receptor A (ETA) antagonist. Suppresses the ET-1-induced decrease of LPL activity. Shows protective effects in ischemic acute renal failure. Neuroprotective. Anti-hypertensive. Inhibits ET-1 receptor binding and blocks Ca2+ mobilization, cellular contraction and MAP kinase activation. Cardiovascular agent. Reduces myocardial infarct size and oxidant injury. Selected Reviews.

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Catalog Number	AG-CP3-0001-M001
Alternative Name(s)	Endothelin Receptor A Antagonist BQ-123; cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu) . Na
Research Area	Biochemicals, Inflammation, Metabolism, Neurobiology
Molecular Formula	C31H42N6O7 . Na
CAS#	136655-57-7
Purity	>98%
Inchi	InChI=1S/C31H42N6O7.Na/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21;/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39);/q;+1/p-1/t21-,22-,23-,24+,26-;/m1./s1
Inchi Key	FLIKEIGEOXCRRG-DRBUQPBJSA-M
SMILES	[Na+].CC(C)CC1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC([O-])=O)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC1=O)C(C)C
Size	1 mg
Supplier Page	http://www.adipogen.com/ag-cp3-0001/bq-123-sodium-salt.html