proTAME Solution
Cell permeable prodrug capable of inducing mitotic arrest and cell death in HeLa and other cell types. Inhibitor of the ubiquitin ligase activity of the anaphase-promoting complex/cyclosome (APC/C) by preventing its activation by Cdc20 and Cdh1. proTAME is converted to its active parent molecule (TAME; Tosyl-L-arginine methyl ester) by intracellular esterases.
| Catalog Number | AG-CS1-0100-M001 |
| Alternative Name(s) | pro-Tosyl-L-Arginine Methyl Ester |
| Research Area | Biochemicals, Cancer, Cell Death |
| Molecular Formula | C34H38N4O12S |
| CAS# | 1362911-19-0 |
| Purity | >90% |
| Inchi | InChI=1S/C34H38N4O12S/c1-24-15-17-27(18-16-24)51(44,45)38-28(31(41)46-2)14-9-19-35-32(36-33(42)49-22-47-29(39)20-25-10-5-3-6-11-25)37-34(43)50-23-48-30(40)21-26-12-7-4-8-13-26/h3-8,10-13,15-18,28,38H,9,14,19-23H2,1-2H3,(H2,35,36,37,42,43)/t28-/m0/s1 |
| Inchi Key | MHYOVHULCQSDRZ-NDEPHWFRSA-N |
| SMILES | COC(=O)[C@H](CCCNC(NC(=O)OCOC(=O)CC1=CC=CC=C1)=N/C(=O)OCOC(=O)CC1=CC=CC=C1)NS(=O)(=O)C1=CC=C(C)C=C1 |
| Size | 1 mg |
| Supplier Page | http://www.adipogen.com/ag-cs1-0100/protame-solution.html |