Z-Leu-Leu-Leu-CHO [MG-132]

Potent, cell permeable and selective, reversible proteasome inhibitor. Blocks degradation of short-lived proteins and induces a heat shock response. NF-kappaB activation inhibitor through IkappaB degradation. Cell permeable, reversible peptide aldehyde inhibitor. Calpain and cathepsin inhibitor. Has anticancer properties by inducing cell cycle arrest and activating apoptosis in various cancer cell lines. Has adjuvant/chemosensitizer potential. Neurite outgrowth stimulator in PC12 cells. Prevents beta-secretase cleavage. Autophagy activator.

Price Not Available 5 mg Z-Leu-Leu-Leu-CHO [MG-132] Supplier Page
Catalog Number AG-CP3-0011-M005
Alternative Name(s) Z-LLL-CHO; Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal; MG132
Research Area Apoptosis, Autophagy, Biochemicals, Cancer, Cell Death, Immunology, Inflammation, Neurodegenerative Disease
Molecular Formula C26H41N3O5
CAS# 133407-82-6
Purity >97%
Inchi InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
Inchi Key TZYWCYJVHRLUCT-VABKMULXSA-N
SMILES [H]C(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(CC(C)C)NC(=O)OCC1=CC=CC=C1
Size 5 mg
Supplier Page http://www.adipogen.com/ag-cp3-0011/mg-132.html