Verruculogen

Fumitremorgin-type alkaloid. Tremorgenic neurotoxic mycotoxin. Selective blocker of KCa1.1 (high-conductance Ca2+-activated K+; BK; maxi-K) channels. Decreases GABA levels in CNS. Increases spontaneous glutamate and aspartate release. At toxic doses, increases the number and decreases the affinity of DHP receptors in rat cortex. Cell cycle inhibitor at the M phase. Inhibits calmodulin and PKC activity. Has apoptotic effects on human T lymphocytes. Stimulates the growth of seedling roots of buckwheat.

Price Not Available 1 mg Verruculogen Supplier Page
Catalog Number BVT-0443-M001
Alternative Name(s) NA 209A; TR 1
Research Area Antibiotic, Apoptosis, Biochemicals, Cancer, Cell Death, Natural Products, Necrosis, Neurobiology
Molecular Formula C27H33N3O7
CAS# 12771-72-1
Purity >98%
Inchi InChI=1S/C27H33N3O7/c1-14(2)11-20-29-18-12-15(35-5)8-9-16(18)21-22(29)19(13-26(3,4)37-36-20)30-24(32)17-7-6-10-28(17)25(33)27(30,34)23(21)31/h8-9,11-12,17,19-20,23,31,34H,6-7,10,13H2,1-5H3/t17-,19-,20+,23-,27+/m0/s1
Inchi Key LRXYHMMJJCTUMY-GWXUGYLUSA-N
SMILES [H][C@@]12CCCN1C(=O)[C@]1(O)[C@@H](O)C3=C4N(C5=C3C=CC(OC)=C5)[C@]([H])(OOC(C)(C)C[C@]4([H])N1C2=O)C=C(C)C
Size 1 mg
Supplier Page http://www.adipogen.com/bvt-0443/verruculogen.html