Kdo2-Lipid A (ready-to-use)

Defined substructure of the Re mutant of lipopolysaccharide (LPS). Endotoxin activity equal to Re LPS. Strong activator (<10ng/ml) of macrophages via toll-like receptor 4 (TLR4). Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice by IL-6 ELISA. Facilitates the structural analysis of its complexes with signaling receptors, such as TLR4/MD2 and CD14. Kdo2-Lipid A was used in a recent animal atherosclerosis model. Induces sphingolipid biosynthesis, which is essential for induction of autophagy.

Catalog Number AG-CU1-0001-M001
Alternative Name(s) (3-Deoxy-D-manno-octulosonic acid)2-Lipid A
Research Area Autophagy, Biochemicals, Inflammation, Natural Products
Molecular Formula C110H198N2Na4O39P2
CAS# 123621-04-5 (free base)
Inchi InChI=1S/C110H202N2O39P2.4H3N/c1-7-13-19-25-31-37-38-44-50-56-62-68-92(123)142-82(66-60-54-48-42-35-29-23-17-11-5)72-94(125)146-104-96(112-90(121)71-81(65-59-53-47-41-34-28-22-16-10-4)141-91(122)67-61-55-49-43-36-30-24-18-12-6)105(144-88(102(104)150-152(133,134)135)78-140-109(107(129)130)74-86(98(127)101(148-109)85(119)76-114)147-110(108(131)132)73-83(117)97(126)100(149-110)84(118)75-113)139-77-87-99(128)103(145-93(124)70-80(116)64-58-52-46-40-33-27-21-15-9-3)95(106(143-87)151-153(136,137)138)111-89(120)69-79(115)63-57-51-45-39-32-26-20-14-8-2;;;;/h79-88,95-106,113-119,126-128H,7-78H2,1-6H3,(H,111,120)(H,112,121)(H,129,130)(H,131,132)(H2,133,134,135)(H2,136,137,138);4*1H3/t79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,109-,110-;;;;/m1../s1
Inchi Key HBSUHPVFGADBOQ-USMMBHRMSA-N
SMILES [Na+].[Na+].[Na+].[Na+].CCCCCCCCCCCCCC(=O)O[C@H](CCCCCCCCCCC)CC(=O)OC1[C@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@H](OCC2O[C@H](OP(O)([O-])=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)C(OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H]2O)OC(CO[C@@]2(CC(O[C@@]3(CC(O)[C@@H](O)C(O3)[C@@H](O)CO)C([O-])=O)[C@@H](O)C(O2)[C@@H](O)CO)C([O-])=O)[C@H]1OP(O)([O-])=O
Size 1 mg
Supplier Page http://www.adipogen.com/ag-cu1-0001/kdo2-lipid-a-ready-to-use.html