Interferon alfacon-1

Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional amino acid changes were made to facilitate the molecular construction, and a corresponding synthetic DNA sequence was constructed using chemical synthesis methodology. Interferon alfacon-1 differs from interferon alfa-2b at 20/166 amino acids (88% homology), and comparison with interferon-beta shows identity at over 30% of the amino acid positions. Interferon alfacon-1 is produced in Escherichia coli (E. coli) cells that have been genetically altered by insertion of a synthetically constructed sequence that codes for Interferon alfacon-1. Prior to final purification, Interferon alfacon-1 is allowed to oxidize to its native state, and its final purity is achieved by sequential passage over a series of chromatography columns. This protein has a molecular weight of 19,434 daltons.

Price Not Available 1 mg Interferon alfacon-1 Supplier Page
Trivial name IFNA2
Catalog Number TP-037CL
Alternative Name(s) Interferon alfacon-1
Research Area Immunoregulation
Molecular Formula C860H1353N227O255S9
CAS# 118390-30-0
Purity >90%
Size 1 mg
Supplier Page https://www.creativebiolabs.net/Interferon-alfacon-1-22375.htm
Additional Information For the treatment of hairy cell leukemia, malignant melanoma, and AIDS-related Kaposi's sarcoma