Boc-Leu-Arg-Arg-AMC
Fluorogenic tri-peptide substrate for measuring the trypsin-like peptidase activity of the 20S proteasome. Substrate for the Kex2 endopeptidase from S. Cervisiae, which has substrate specificity toward the C-terminal side of LR, PR and RR sequences. Can be cleaved by Kallikrein 5 with a P1 site preference for basic residues (R and K). Excitation: 380nm. Emission: 460nm. This substrate is useful for inhibitor screening and kinetic analysis.
| Catalog Number | AG-CP3-0014-M005 |
| Alternative Name(s) | Boc-LRR-AMC . AcOH; Proteasome Substrate |
| Research Area | Biochemicals, Cancer, Immunology |
| Molecular Formula | C33H52N10O7 . C2H4O2 |
| CAS# | 109358-46-5 (free base) |
| Purity | >98% |
| Inchi | InChI=1S/C33H52N10O7.C2H4O2/c1-18(2)15-24(43-32(48)50-33(4,5)6)29(47)42-23(10-8-14-39-31(36)37)28(46)41-22(9-7-13-38-30(34)35)27(45)40-20-11-12-21-19(3)16-26(44)49-25(21)17-20;1-2(3)4/h11-12,16-18,22-24H,7-10,13-15H2,1-6H3,(H,40,45)(H,41,46)(H,42,47)(H,43,48)(H4,34,35,38)(H4,36,37,39);1H3,(H,3,4)/t22-,23-,24-;/m0./s1 |
| Inchi Key | ZYZDREMHVGIZMZ-NYTZCTPBSA-N |
| SMILES | Cl.CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC1=CC2=C(C=C1)C(C)=CC(=O)O2 |
| Size | 5 mg |
| Supplier Page | http://www.adipogen.com/ag-cp3-0014/boc-leu-arg-arg-amc.html |