Ruxolitinib . phosphate salt

Water-soluble phosphate salt of Ruxolitinib. Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM). Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro.

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Catalog Number	AG-CR1-3645-M005
Alternative Name(s)	INCB018424; INC 424
Research Area	Apoptosis, Autophagy, Biochemicals, Cancer, Immunology, Inflammation
Molecular Formula	C17H18N6 . H3O4P
CAS#	1092939-17-7
Purity	>97%
Inchi	InChI=1S/C17H18N6.H3O4P/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16;1-5(2,3)4/h6,8-12,15H,1-5H2,(H,19,20,21);(H3,1,2,3,4)/t15-;/m1./s1
Inchi Key	JFMWPOCYMYGEDM-XFULWGLBSA-N
SMILES	N#CC[C@H](C1CCCC1)N(N=C2)C=C2C3=NC=NC4=C3C=CN4.OP(O)(O)=O
Size	5 mg
Supplier Page	http://www.adipogen.com/ag-cr1-3645/ruxolitinib-phosphate-salt.html