Ascomycin (high purity)

Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin (protein phosphatase 2B (PP2B)). Suppresses the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant (antiepileptic).

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Catalog Number	AG-CN2-0420-M005
Alternative Name(s)	Immunomycin; FK520; Analog of FK-506; FR-900520; L-683590; NSC 106410; WS 7238A
Research Area	Antibiotic, Immunology, Inflammation, Natural Products, Neurobiology, Neurodegenerative Disease
Molecular Formula	C43H69NO12
CAS#	104987-12-4
Purity	>98%
Inchi	InChI=1S/C43H69NO12/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)44-16-12-11-13-31(44)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-32(45)35(22-29)52-7/h18,20,25,27-33,35-39,45-46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+/t25-,27+,28+,29-,30+,31-,32+,33-,35?,36?,37?,38+,39+,43+/m0/s1
Inchi Key	ZDQSOHOQTUFQEM-VZQNCADUSA-N
SMILES	[H][C@]12O[C@](O)([C@H](C)C[C@@H]1OC)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@@H]([C@H](C)[C@@H](O)CC(=O)[C@H](CC)C=C(C)C[C@H](C)C[C@@H]2OC)C(C)=C[C@@H]1CC[C@@H](O)[C@@H](C1)OC
Size	5 mg
Supplier Page	http://www.adipogen.com/ag-cn2-0420/ascomycin-high-purity.html