Ascomycin (high purity)

Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin (protein phosphatase 2B (PP2B)). Suppresses the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant (antiepileptic).

Price Not Available 25 mg Ascomycin (high purity) Supplier Page

Catalog Number	AG-CN2-0420-M025
Alternative Name(s)	Immunomycin; FK520; Analog of FK-506; FR-900520; L-683590; NSC 106410; WS 7238A
Research Area	Antibiotic, Immunology, Inflammation, Natural Products, Neurobiology, Neurodegenerative Disease
Molecular Formula	C43H69NO12
CAS#	104987-12-4
Purity	>98%
Inchi	InChI=1S/C43H69NO12/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)44-16-12-11-13-31(44)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-32(45)35(22-29)52-7/h18,20,25,27-33,35-39,45-46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+/t25-,27+,28+,29-,30+,31-,32+,33-,35?,36?,37?,38+,39+,43+/m0/s1
Inchi Key	ZDQSOHOQTUFQEM-VZQNCADUSA-N
SMILES	[H][C@]12O[C@](O)([C@H](C)C[C@@H]1OC)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@@H]([C@H](C)[C@@H](O)CC(=O)[C@H](CC)C=C(C)C[C@H](C)C[C@@H]2OC)C(C)=C[C@@H]1CC[C@@H](O)[C@@H](C1)OC
Size	25 mg
Supplier Page	http://www.adipogen.com/ag-cn2-0420/ascomycin-high-purity.html