Gardiquimod
Immune response modifier. Antiviral and antitumor compound Selective ligand for human or mouse Toll-like receptor 7 (TLR7). Induces the activation of NF-kappaB in HEK 293 cells expressing TLR7 at 0.1µg/ml. 10 times more active than Imiquimod (Prod. No. AG-CR1-3569 http://www.adipogen.com/ag-cr1-3569/imiquimod.html ). At high concentrations (3µg/ml) slightly activates TLR8. Shows adjuvant activity to increase the effectiveness of vaccines.
| Catalog Number | AG-CR1-3583-M005 |
| Alternative Name(s) | 1-(4-Amino-2-ethylaminomethylimidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol |
| Research Area | Apoptosis, Biochemicals, Cancer, Cell Death, Inflammasomes, Inflammation |
| Molecular Formula | C17H23N5O |
| CAS# | 1020412-43-4 |
| Purity | >98% |
| Inchi | InChI=1/C17H23N5O/c1-4-19-9-13-21-14-15(22(13)10-17(2,3)23)11-7-5-6-8-12(11)20-16(14)18/h5-8,19,23H,4,9-10H2,1-3H3,(H2,18,20)/f/h18H2 |
| Inchi Key | FHJATBIERQTCTN-DZQCGVKKCV |
| SMILES | CCNCC1=NC2=C(N1CC(C)(C)O)C1=C(C=CC=C1)N=C2N |
| Size | 5 mg |
| Supplier Page | http://www.adipogen.com/ag-cr1-3583/gardiquimod.html |