Creative Biolabs is a leading company of recombinant antibody (rAb) discovery and manufacturing, providing high quality service to customers in academia and industry fields all over the world. Our cutting-edge hybridoma development and phage display platforms allow the production of the most comprehensive list of recombinant antibody products and extensive service portfolio at the most competitive price.
Company WebsiteADCs Toxins, Potent inhibitor of the mitochondrial and bacterial type I NADH-ubiquinone oxireductase. HCT-116: IC50=0,020 uM; PSN1 : IC50=12,03 uM; T98G : IC50=>12,03 uM; A549 : IC50=>12,03 uM (preliminary laboratory results). Journal of cellular physiology (2008), 215(1), 243-50.
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ADCs Toxins, Pironetin is a potent inhibitor of tubulin. Pironetin covalently binds tubulin. Systematic alanine scanning shows, that the pironetin binding site was determined to be Lys352 of alpha-tubulin. Lys352 is located at the entrance of a small pocket of alpha-tubulin, and this pocket faces the beta-tubulin of the next dimer. This is the first […]
More Information Supplier PageADCs cytotoxin, PNU-159682 is a major bioactive metabolite of Nemorubicin in human liver microsomes; > 3,000-fold cytotoxic than its parent compound(MMDX and doxorubicin).
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ADCs Toxins, Potent Inhibitor of microtubule assembly an DNA topoisomerase II
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ADCs Toxins, Polyketomycin is a tetracyclic quinone glycoside. Polyketomycin shows antibacterial, antimalarial and antitumor activity.
More Information Supplier PagePramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes.
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ADCs Toxins, Pseudolaric acid B (PAB) is a diterpene acid isolated from the bark of P. kaempferi, a traditional Chinese medicinal plant. It has reported antifungal activities, consistent with its traditional use in the treatment of dermatological fungal infections. Moreover, PAB has diverse effects that are relevant to cancer therapy, including inducing apoptosis of cancer […]
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ADCs Toxins, Pseurotin A is an antibiotic and cytotoxic compound. Pseurotin A shows nematicidal activity.
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ADCs Toxins, Quinaldopeptin is a quinomycin antibiotic isolated from an Amycolatopsis sp. with strong antimicrobial and cytotoxic activity. The symmetric cyclic peptide structure of Quinaldopeptin contains two intercalating naphtyl moieties which produce a bis-intercalation of DNA base pairs, creating DNA crosslinks and disturbing natural DNA processes. Quinaldopeptin is demonstrated to have high efficacy against gram-positive […]
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Ranibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment designed for intraocular use. Ranibizumab binds to and inhibits the biologic activity of human vascular endothelial growth factor A (VEGF-A). Ranibizumab has a molecular weight of approximately 48 kilodaltons and is produced by an E. coli expression system in a nutrient medium containing the […]
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Antibody array is a specific form of protein microarray. In this technology, capture antibodies spotted on membranes or glass slide bind to specific target proteins present in the sample. Captured proteins are visualized using chemiluminescent or Laser Scanner. The signal produced is proportional to the amount of analyte bound. The Rat Cytokine Antibody Array detects […]
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ADCs Toxins, An antibiotic composed of a halogenated indolocarbazole chromophore linked via N-glycosidic bond to a glucose derivative. It intercalates into the DNA and is an inhibitor of topoisomerase I. L1210: IC50 = 100 nM (mouse); K562: IC50 = 200 nM (human); A549: IC50 = 300 nM (human); B16 melanoma cells: IC50 = 480 nM […]
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Recombinant human antibody Fab fragment to Omalizumab/hIgE. This product is an anti-idiotypic human Fab antibody which is specific for the Omalizumab/hIgE complex. It can be used for ELISA and other assays.
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This product is a Dsred encoding oncolytic herpes simplex virus, which is based on HSV-1 with ICP27 deleted. ICP27 is highly cytotoxic probably due to its secondary role of preventing the splicing of pre-mRNAs in favour of translation from the mainly unspliced hepes RNAs. Deletion of ICP27 might produce a safer and less cytotoxic system […]
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This product is a EGFP encoding oncolytic herpes simplex virus, which is based on HSV-1 with ICP27 deleted. ICP27 is highly cytotoxic probably due to its secondary role of preventing the splicing of pre-mRNAs in favour of translation from the mainly unspliced hepes RNAs. Deletion of ICP27 might produce a safer and less cytotoxic system […]
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This product is a GFP encoding oncolytic herpes simplex virus, which is based on HSV-1 with ICP27 deleted. ICP27 is highly cytotoxic probably due to its secondary role of preventing the splicing of pre-mRNAs in favour of translation from the mainly unspliced hepes RNAs. Deletion of ICP27 might produce a safer and less cytotoxic system […]
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This product is a lacZ encoding oncolytic herpes simplex virus, which is based on HSV-1 with ICP27 deleted. ICP27 is highly cytotoxic probably due to its secondary role of preventing the splicing of pre-mRNAs in favour of translation from the mainly unspliced hepes RNAs. Deletion of ICP27 might produce a safer and less cytotoxic system […]
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This product is a luciferase encoding oncolytic herpes simplex virus, which is based on HSV-1 with ICP27 deleted. ICP27 is highly cytotoxic probably due to its secondary role of preventing the splicing of pre-mRNAs in favour of translation from the mainly unspliced hepes RNAs. Deletion of ICP27 might produce a safer and less cytotoxic system […]
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This product is a Dsred encoding oncolytic herpes simplex virus, which is based on HSV-1 with ICP34.5 and UNG deleted. ICP34.5 protein, is important for viral replication, viral exit from infected cells, prevention of the premature shut-off of protein synthesis in the infected host, and neurovirulence. Uracil DNA glycosylase (UNG, UDG) is the most abundant […]
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This product is a EGFP encoding oncolytic herpes simplex virus, which is based on HSV-1 with ICP34.5 and UNG deleted. ICP34.5 protein, is important for viral replication, viral exit from infected cells, prevention of the premature shut-off of protein synthesis in the infected host, and neurovirulence. Uracil DNA glycosylase (UNG, UDG) is the most abundant […]
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This product is a GFP encoding oncolytic herpes simplex virus, which is based on HSV-1 with ICP34.5 and UNG deleted. ICP34.5 protein, is important for viral replication, viral exit from infected cells, prevention of the premature shut-off of protein synthesis in the infected host, and neurovirulence. Uracil DNA glycosylase (UNG, UDG) is the most abundant […]
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This product is a lacZ encoding oncolytic herpes simplex virus, which is based on HSV-1 with ICP34.5 and UNG deleted. ICP34.5 protein, is important for viral replication, viral exit from infected cells, prevention of the premature shut-off of protein synthesis in the infected host, and neurovirulence. Uracil DNA glycosylase (UNG, UDG) is the most abundant […]
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Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a “third-generation” thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids present in endogenous human tPA. Retavase contains 355 of the 527 […]
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Rituxan is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light- and heavy-chain variable region sequences and human constant region sequences. Rituximab is composed of two heavy chains of 451 amino acids […]
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ADCs Toxins, Ro 5-3335 is described to kill human leukemia cell lines with CBF fusion proteins. The IC50 value – 1.1 µM.
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ADCs Toxins, Safracin B is an novel antibiotic compound produced by Pseudomonas fluorescens. Safracin B showed antitumor activity against L1210 and P388 leukemias and B16 melanoma.Early research indicates that the alpha-carbinolamine structure may plays an important role in the antitumor action of this type of antibiotic.
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ADCs Toxins, The small molecule Rebeccamycin is an indolocarbazole antibiotic, functional as an inhibitor DNA topoisomerase I. The stereochemistry of the pendant sugar on Rebeccamycin is demonstrated to be crucial for the specificity of this DNA interaction. HCT-116: IC50=0,000082 uM; PSN1 : IC50=0,041 uM; T98G : IC50=0,00082 uM; A549 : IC50=0,00041 uM (preliminary laboratory results).
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ADCs Toxins, Sanguinarine is a natrually isolated benzophenanthridine alkaloide. Sanguinarine exhibits several beneficial properties like: chemotherapeutic, anti-inflammatory and antibacterial activities. Sanguinarine increases oxidative stress and induces DNA damage in species of Microcystatis, a cyanobacterium, inhibiting cell division.
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Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
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SARS-CoV-2 -N1 Forward Primer https://sars-cov-2.creative-biolabs.com/sars-cov-2-n1-f-238.htm
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Tumor associated glycoprotein (TAG) 72 (B72.3) monoclonal antibody conjugated with Indium 111 for radioimaging colon tumors. Satumomab Pendetide (trade name: OncoScint®) is no longer commercially available.
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Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues
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ADCs Toxins, Sinefungin blocks the methylation of bases in DNA and RNA. Sinefungin is also involved in physiological processes such as aging and carcinogenesis.
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ADCs linker, SMCC is a noncleavable linker for antibody-drug-conjugation (ADC).
More Information Supplier PageLinker-Toxin SET, This set is made by DM1 conjugated to SMCC linker. DM1 belongs to Maytansinoids which are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in […]
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Recombinant human growth hormone (somatotropin) 191 residues, MW 22.1 kD, synthesized in E. coli
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Long-QT syndromes are heritable diseases associated with prolongation of the QT interval on an electrocardiogram and a high risk of sudden cardiac death due to ventricular tachyarrhythmia. This disease cell model belongs to long-QT syndrome type 1, mutation (P631fs/33, also called 1893delC) occur in the KCNQ1 gene. Generating pluripotent stem cells from dermal fibroblasts, then […]
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