AdipoGen Life Sciences

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AdipoGen Life Sciences develops and manufactures new products for the Life Science Research Market in the key areas of cancer, immunology, inflammation, metabolic syndrome (diabetes, obesity), stem cell biology, and neurodegeneration. The product portfolio consists of antibodies, proteins, ELISA Kits and innovative small molecules. The chemical portfolio includes, rare antibiotics, unique natural products, synthetic kinase modulators, fluorescent probes and much more.

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M-Phisyl-chloride 100 mg  | >97%

AdipoGen Life Sciences

It is known that phenol and p-cresol are promoters of skin tumors and also urinary excretion of phenol and p-cresol is increased by exposure to benzene, which has hemopoietic toxicity, and toluene, respectively. Therefore, the determination of phenol and p-cresol is important in clinical chemistry and toxicology. Because phenol and p-cresol are present in urine […]

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M-Phisyl-chloride 500 mg  | >97%

AdipoGen Life Sciences

It is known that phenol and p-cresol are promoters of skin tumors and also urinary excretion of phenol and p-cresol is increased by exposure to benzene, which has hemopoietic toxicity, and toluene, respectively. Therefore, the determination of phenol and p-cresol is important in clinical chemistry and toxicology. Because phenol and p-cresol are present in urine […]

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Macrosporin 1 mg  | >98%

AdipoGen Life Sciences

Anthraquinone antibiotic. Moderate antibacterial agent. Photosensitizer (through ROS production) and leaf necrosis inducer. Antiproliferative. Moderate cytotoxic in selected cancer cells. Shown to inhibit several protein kinases, including Aurora B and FLT3 in low µM range. Mycotoxin. Useful as a reference in food analysis.

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Makisterone A 250 µg  | >95%

AdipoGen Life Sciences

A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. Induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes. Plays a role in insect development, cell proliferaton, growth and apoptosis by controlling gene expression involved in moulting and […]

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Makisterone A 1 mg  | >95%

AdipoGen Life Sciences

A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. Induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes. Plays a role in insect development, cell proliferaton, growth and apoptosis by controlling gene expression involved in moulting and […]

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Makisterone A 5 mg  | >95%

AdipoGen Life Sciences

A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. Induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes. Plays a role in insect development, cell proliferaton, growth and apoptosis by controlling gene expression involved in moulting and […]

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Malformin A1 250 µg  | >95%

AdipoGen Life Sciences

Peptide antibiotic. Antibcaterial. Plant growth stimulator. Induces root curvature and malformation in plants. Mycotoxin. Prevents interleukin-1 (IL-1) induced endothelial changes by inhibition of protein synthesis. Inhibitor of interleukin-1 beta (IL1 beta) binding to its receptor. Enhancer of cellular fibrinolytic activity. Disrupts the cell cycle at the G2 checkpoint of cancer cells, leading to sensitization of […]

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Malformin A1 1 mg  | >95%

AdipoGen Life Sciences

Peptide antibiotic. Antibcaterial. Plant growth stimulator. Induces root curvature and malformation in plants. Mycotoxin. Prevents interleukin-1 (IL-1) induced endothelial changes by inhibition of protein synthesis. Inhibitor of interleukin-1 beta (IL1 beta) binding to its receptor. Enhancer of cellular fibrinolytic activity. Disrupts the cell cycle at the G2 checkpoint of cancer cells, leading to sensitization of […]

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Malformin C 250 µg  | >95%

AdipoGen Life Sciences

Peptide antibiotic. Induces root curvature and malformation in plants. Antibacterial, antimalarial and antitrypanosomal. Disrupts the cell cycle at the G2 checkpoint of cancer cells, leading to sensitization of the cancer cells to anti-cancer reagents.

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Malformin C 1 mg  | >95%

AdipoGen Life Sciences

Peptide antibiotic. Induces root curvature and malformation in plants. Antibacterial, antimalarial and antitrypanosomal. Disrupts the cell cycle at the G2 checkpoint of cancer cells, leading to sensitization of the cancer cells to anti-cancer reagents.

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Manumycin A 1 mg  | >96%

AdipoGen Life Sciences

Antibiotic. Apoptosis and endoplasmic reticulum stress-mediated cell death inducer. Potent, selective and competitive cell permeable rasfarnesyltransferase inhibitor (IC50 = 30 nM). Does not affect geranylgeranyltransferase (IC50 = 180 µM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Neutral sphingomyelinase inhibitor. Blocks insulin-induced MAP kinase activation in rat cardiac myocytes […]

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Manumycin A 5 mg  | >96%

AdipoGen Life Sciences

Antibiotic. Apoptosis and endoplasmic reticulum stress-mediated cell death inducer. Potent, selective and competitive cell permeable rasfarnesyltransferase inhibitor (IC50 = 30 nM). Does not affect geranylgeranyltransferase (IC50 = 180 µM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Neutral sphingomyelinase inhibitor. Blocks insulin-induced MAP kinase activation in rat cardiac myocytes […]

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Manumycin A 10 mg  | >96%

AdipoGen Life Sciences

Antibiotic. Apoptosis and endoplasmic reticulum stress-mediated cell death inducer. Potent, selective and competitive cell permeable rasfarnesyltransferase inhibitor (IC50 = 30 nM). Does not affect geranylgeranyltransferase (IC50 = 180 µM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Neutral sphingomyelinase inhibitor. Blocks insulin-induced MAP kinase activation in rat cardiac myocytes […]

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Manumycin B 1 mg  | >98%

AdipoGen Life Sciences

Antibiotic. Antibacterial. Active against Gram-positive bacteria. Rasfarnesyltransferase inhibitor. Apoptosis (Caspase-1) inhibitor. AChE inhibitor.

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Manumycin B 5 mg  | >98%

AdipoGen Life Sciences

Antibiotic. Antibacterial. Active against Gram-positive bacteria. Rasfarnesyltransferase inhibitor. Apoptosis (Caspase-1) inhibitor. AChE inhibitor.

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Manzamine A 500 µg  | >98%

AdipoGen Life Sciences

Antibiotic. Antibacterial against Gram positive and Gram negative bacteria. Exhibits chemotherapeutic activity. Blocks tumor cell invasion and restores cancer cell susceptibility to apoptosis in vitro. Uncouples vacuolar ATPases, inhibiting autophagy and tumor growth. Antimalaria, antifungal and antiviral agent. GSK-3beta inhibitor. Anti-Alzheimer’s agent. Decreased tau hyperphosphorylation. Anti-hyperlipidemic. Inhibits cholesterol ester formation and acyl-CoA:cholesterol acyl-transferase (ACAT) activity […]

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MBIMPH 1 mg  | >98%

AdipoGen Life Sciences

Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =9nM). Displays high selectivity over all other HDACs (IC50=0.1-12µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (Prod. No. AG-CR1-3900). HDAC6 deacetylates tubulin, HSP90 and the core […]

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MBIMPH 5 mg  | >98%

AdipoGen Life Sciences

Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =9nM). Displays high selectivity over all other HDACs (IC50=0.1-12µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (Prod. No. AG-CR1-3900). HDAC6 deacetylates tubulin, HSP90 and the core […]

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MBIMPH F-Analog 1 . hydrochloride 1 mg  | >95%

AdipoGen Life Sciences

Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =3nM). Displays high selectivity over all other HDACs (IC50=0.03-20µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (AG-CR1-3900). HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, […]

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MBIMPH F-Analog 1 . hydrochloride 5 mg  | >95%

AdipoGen Life Sciences

Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =3nM). Displays high selectivity over all other HDACs (IC50=0.03-20µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (AG-CR1-3900). HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, […]

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MBIMPH F-Analog 2 1 mg  | >95%

AdipoGen Life Sciences

Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =5nM). Displays high selectivity over all other HDACs (IC50=0.2-11µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (AG-CR1-3900). HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, […]

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MBIMPH F-Analog 2 5 mg  | >95%

AdipoGen Life Sciences

Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =5nM). Displays high selectivity over all other HDACs (IC50=0.2-11µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (AG-CR1-3900). HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, […]

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MCC950 . Na 1 mg  | >98%

AdipoGen Life Sciences

Potent, selective and orally available NLRP3 inflammasome inhibitor. Blocks the release of IL-1beta in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1, NLRC4, AIM2, TLR2 signaling or priming of NLRP3. Prevents oligomerization of ASC in cells stimulated with LPS and nigericin. Active in vivo, blocking the production […]

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MCC950 . Na 5 mg  | >98%

AdipoGen Life Sciences

Potent, selective and orally available NLRP3 inflammasome inhibitor. Blocks the release of IL-1beta in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1, NLRC4, AIM2, TLR2 signaling or priming of NLRP3. Prevents oligomerization of ASC in cells stimulated with LPS and nigericin. Active in vivo, blocking the production […]

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MCC950 . Na 10 mg  | >98%

AdipoGen Life Sciences

Potent, selective and orally available NLRP3 inflammasome inhibitor. Blocks the release of IL-1beta in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1, NLRC4, AIM2, TLR2 signaling or priming of NLRP3. Prevents oligomerization of ASC in cells stimulated with LPS and nigericin. Active in vivo, blocking the production […]

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Me4BodipyFL-Ahx3Leu3VS 50 µg  | >95%

AdipoGen Life Sciences

Cell permeable fluorescent proteasome activity probe. Allows for high sensitive accurate profiling of proteasomal activity in cell lysates, intact cells and murine/human patient-derived material.

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Me6BIO 5 mg  | >95%

AdipoGen Life Sciences

N-methylated inactive control analog of 6-bromoindirubin-3′-oxime (6BIO) (Prod. No. MR-C0019). Displays minimal activity against CDK1/Cyclin B, GSK-3 alpha/beta and CDK5/p25. Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.

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Me6BIO 25 mg  | >95%

AdipoGen Life Sciences

N-methylated inactive control analog of 6-bromoindirubin-3′-oxime (6BIO) (Prod. No. MR-C0019). Displays minimal activity against CDK1/Cyclin B, GSK-3 alpha/beta and CDK5/p25. Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.

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Me7BIO 5 mg  | >95%

AdipoGen Life Sciences

N-methylated inactive control compound for 7BIO (Prod. No. MR-C0020). Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.

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Me7BIO 25 mg  | >95%

AdipoGen Life Sciences

N-methylated inactive control compound for 7BIO (Prod. No. MR-C0020). Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.

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Mefluidide 50 mg  | >98%

AdipoGen Life Sciences

Trifluoromethanesulphonanilide herbicide. Plant growth regulator based on the inhibition of distinct 3-ketoacyl-CoA synthase (KCS) isoenzymes in very-long-chain fatty acid (VLCFA) synthesis. Dependent on the affected KCS isoenzymes and the intensity of inhibition, plant phenotypes are induced which are characterized by shoot stunting with intensified green pigmentation or strong growth inhibition followed by tissue necrosis and […]

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Mefluidide 500 mg  | >98%

AdipoGen Life Sciences

Trifluoromethanesulphonanilide herbicide. Plant growth regulator based on the inhibition of distinct 3-ketoacyl-CoA synthase (KCS) isoenzymes in very-long-chain fatty acid (VLCFA) synthesis. Dependent on the affected KCS isoenzymes and the intensity of inhibition, plant phenotypes are induced which are characterized by shoot stunting with intensified green pigmentation or strong growth inhibition followed by tissue necrosis and […]

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MEGA-8 (ultrapure) 1 g  | >99%

AdipoGen Life Sciences

Non-ionic water-soluble detergent with nondenaturing properties. Transparent in the UV region. Relatively high critical micelle concentration (CMC) value (79mM/l). Ideal for studying the conformation and function of proteins, keeping the secondary and tertiary structure intact, therefore suited for solubilizing membrane proteins without altering biological activity. Efficiently separates hydrophilic proteins from membrane spanning, hydrophobic proteins. Ideal […]

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MEGA-8 (ultrapure) 5 g  | >99%

AdipoGen Life Sciences

Non-ionic water-soluble detergent with nondenaturing properties. Transparent in the UV region. Relatively high critical micelle concentration (CMC) value (79mM/l). Ideal for studying the conformation and function of proteins, keeping the secondary and tertiary structure intact, therefore suited for solubilizing membrane proteins without altering biological activity. Efficiently separates hydrophilic proteins from membrane spanning, hydrophobic proteins. Ideal […]

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Meglumine 1 g  | >95%

AdipoGen Life Sciences

Used as an excipient (an inert substance) in pharmaceuticals that improves solubility, drug release rate and stabilization of anionic drug substances. Counter ion used to replace sodium. It is impermeable towards cell membranes with comparable osmotic activity like sodium. Widely used in the preparation of contrast/radiopaque media in combination with iodine containing compounds, such as […]

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Meglumine 5 g  | >95%

AdipoGen Life Sciences

Used as an excipient (an inert substance) in pharmaceuticals that improves solubility, drug release rate and stabilization of anionic drug substances. Counter ion used to replace sodium. It is impermeable towards cell membranes with comparable osmotic activity like sodium. Widely used in the preparation of contrast/radiopaque media in combination with iodine containing compounds, such as […]

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Melanin Production Inhibitor A3B5 1 mg  | >98%

AdipoGen Life Sciences

Non-cytotoxic melanogenesis inhibitor. Potential depigmentation agent. Tyrosinase-related protein 2 (TRP-2) expression inhibitor, via proteasomal degradation. Inhibits the proliferation of melanocytes and melanoma cells through cell cycle arrest in G1. Moderate skin tumor growth suppressor in vivo.

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Meleagrin 1 mg  | >90%

AdipoGen Life Sciences

Mycotoxin. Alkaloid antibiotic. Bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor. Antineoplastic activity. Moderate cytotoxicity against A-549 and HL-60 cell lines. Induces cell cycle arrest through G2/M phase, presumably by inhibiting tubulin polymerization. Antifouling agent against the barnacle Balanus amphitrite.

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Menadione 1 g  | >98%

AdipoGen Life Sciences

Synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2 (menaquinone) after alkylation in vivo. The 1,4-naphthoquinone (NQ) moiety can form redox isomers by accepting one or two electrons respectively. The quinone redox cycling ability leads to the generation of reactive oxygen species (ROS) as well as […]

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Menadione 5 g  | >98%

AdipoGen Life Sciences

Synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2 (menaquinone) after alkylation in vivo. The 1,4-naphthoquinone (NQ) moiety can form redox isomers by accepting one or two electrons respectively. The quinone redox cycling ability leads to the generation of reactive oxygen species (ROS) as well as […]

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Meptyldinocap 25 mg  | >98%

AdipoGen Life Sciences

Powdery mildew (Erysiphe necator) dinitrophenol fungicide. Stops cellular energy production. Interferes with fungal respiration by acting as an uncoupler of oxidative phosphorylation. Compound can be used as analytical reference material.

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