AdipoGen Life Sciences

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AdipoGen Life Sciences develops and manufactures new products for the Life Science Research Market in the key areas of cancer, immunology, inflammation, metabolic syndrome (diabetes, obesity), stem cell biology, and neurodegeneration. The product portfolio consists of antibodies, proteins, ELISA Kits and innovative small molecules. The chemical portfolio includes, rare antibiotics, unique natural products, synthetic kinase modulators, fluorescent probes and much more.

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IDA 5 mg  | >90%

AdipoGen Life Sciences

Amino compounds having primary groups such as amino acids or aminocyclitol antibiotics lack chromopores or fluorophores in their molecules. Derivatization is required for their detection with high sensitivity using high-performance liquid chromatography or high-performance apillary electrophoresis with photometric and fluorimetric detection. Reagent for the derivatisation of primary amines. The alanine-derivative shows a 3 times stronger […]

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IDA 25 mg  | >90%

AdipoGen Life Sciences

Amino compounds having primary groups such as amino acids or aminocyclitol antibiotics lack chromopores or fluorophores in their molecules. Derivatization is required for their detection with high sensitivity using high-performance liquid chromatography or high-performance apillary electrophoresis with photometric and fluorimetric detection. Reagent for the derivatisation of primary amines. The alanine-derivative shows a 3 times stronger […]

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IDA 250 mg  | >90%

AdipoGen Life Sciences

Amino compounds having primary groups such as amino acids or aminocyclitol antibiotics lack chromopores or fluorophores in their molecules. Derivatization is required for their detection with high sensitivity using high-performance liquid chromatography or high-performance apillary electrophoresis with photometric and fluorimetric detection. Reagent for the derivatisation of primary amines. The alanine-derivative shows a 3 times stronger […]

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IHR-1 1 mg  | >98%

AdipoGen Life Sciences

Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane impermeable Smoothened (Smo) antagonist. Acts on extracellularly exposed Smo only. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.

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IHR-1 5 mg  | >98%

AdipoGen Life Sciences

Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane impermeable Smoothened (Smo) antagonist. Acts on extracellularly exposed Smo only. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.

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IHR-NAc 1 mg  | >98%

AdipoGen Life Sciences

Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane permeable Smoothened (Smo) antagonist. Acts on extra- and intracellular exposed Smo. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.

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IHR-NAc 5 mg  | >98%

AdipoGen Life Sciences

Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane permeable Smoothened (Smo) antagonist. Acts on extra- and intracellular exposed Smo. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.

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Ilimaquinone 100 µg  | >98%

AdipoGen Life Sciences

Cytoplasmic microtubule inhibitor. Cell permeable, antimicrobial, anti-inflammatory, antimitotic and cytotoxic compound. Induces a complete and reversible breakdown/disruption of Golgi membranes into smaller vesicular structures. Blocks the association of the ADP-ribosylation factor and beta-COP to the Golgi membrane. Blocks protein transport to the plasma membrane and inhibits gap junctional communication. HIV-1 inhibitor. Blocks the cytotoxicity of […]

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Imiquimod 100 mg  | >98%

AdipoGen Life Sciences

Immune response modulator. Anti-inflammatory. TLR7 agonist. Stimulates proinflammatory cytokine production interferon-alpha (IFN-alpha), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) and activates NF-kappaB. Caspase-3 activator that directly induces procaspase-3 cleavage. Anti-cancer compound. Apoptosis inducer. Antiproliferative, independent of immune system activation or function. Antiviral and anti-angiogenic. Approved treatment for external genital warts caused by human papillomavirus infection.

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Imiquimod 250 mg  | >98%

AdipoGen Life Sciences

Immune response modulator. Anti-inflammatory. TLR7 agonist. Stimulates proinflammatory cytokine production interferon-alpha (IFN-alpha), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) and activates NF-kappaB. Caspase-3 activator that directly induces procaspase-3 cleavage. Anti-cancer compound. Apoptosis inducer. Antiproliferative, independent of immune system activation or function. Antiviral and anti-angiogenic. Approved treatment for external genital warts caused by human papillomavirus infection.

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Imperatorin 1 mg  | >98%

AdipoGen Life Sciences

Anticancer compound. Apoptosis inducer. Induces DNA fragmentation at the G1/S phase of the cell cycle. HIV-1 replication inhibitor. Anti-inflammatory. Vasodilatation inducer. Increases BMP-2 expression (mRNA) and enhance bone formation. Modulator of SMAD1/5/8, p38, ERK pathways. Exerts anti-hypertrophic effects. Caspase-1 activity inhibitor in vivo and in vitro. Antibacterial and antilisteria compound. L-Type calcium channel blocker.

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Imperatorin 5 mg  | >98%

AdipoGen Life Sciences

Anticancer compound. Apoptosis inducer. Induces DNA fragmentation at the G1/S phase of the cell cycle. HIV-1 replication inhibitor. Anti-inflammatory. Vasodilatation inducer. Increases BMP-2 expression (mRNA) and enhance bone formation. Modulator of SMAD1/5/8, p38, ERK pathways. Exerts anti-hypertrophic effects. Caspase-1 activity inhibitor in vivo and in vitro. Antibacterial and antilisteria compound. L-Type calcium channel blocker.

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Incensol 1 mg  | >92%

AdipoGen Life Sciences

Component of the frankincense essential oil. Activator of transient receptor potential vanilloid 3 (TRPV3), a heat-sensitive ion channel involved in skin heat sensitivity, thermoregulation and neurological activities. More powerful TRPV3 agonist than incensol acetate (Prod. No. AG-CN2-0484). Potent inhibitor of STAT3. Showed inhibitory activity on IL-6-induced STAT3 activation. Shown to have COX-1 and COX-2 inhibitory […]

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Incensol acetate 1 mg  | >95%

AdipoGen Life Sciences

Component of the frankincense essential oil. Activator of transient receptor potential vanilloid 3 (TRPV3), a heat-sensitive ion channel involved in skin heat sensitivity, thermoregulation and neurological activities. Less powerful TRPV3 agonist than incensol (Prod. No. AG-CN2-0482). Shows in vivo neuroprotective properties. Causes anxiolytic-like and antidepressive-like behavioral effects in wild-type (WT) mice. Anti-inflammatory agent. Shown to […]

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Indo-1 pentapotassium salt 2 mg  | >90%

AdipoGen Life Sciences

Fluorescent calcium chelator and indicator with an unusually large shift in fluorescence emission from 480 nm to 400 nm on binding of calcium. Useful for intracellular application.

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Indo-1 pentapotassium salt 25 mg  | >90%

AdipoGen Life Sciences

Fluorescent calcium chelator and indicator with an unusually large shift in fluorescence emission from 480 nm to 400 nm on binding of calcium. Useful for intracellular application.

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Indole-3-carbinol 500 mg  | >98%

AdipoGen Life Sciences

Natural breakdown product of glucosinolates found in cruciferous vegetables. Widely used multifunctional aryl hydrocarbon receptor (AhR) agonist. AhR is emerging as a transcription factor involved in the regulation of both innate and adaptive immune responses in various immune cell types, including lymphocytes and antigen-presenting cells (APCs). Studies have associated overexpression of AHR with the activation […]

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Indole-3-carbinol 5 g  | >98%

AdipoGen Life Sciences

Natural breakdown product of glucosinolates found in cruciferous vegetables. Widely used multifunctional aryl hydrocarbon receptor (AhR) agonist. AhR is emerging as a transcription factor involved in the regulation of both innate and adaptive immune responses in various immune cell types, including lymphocytes and antigen-presenting cells (APCs). Studies have associated overexpression of AHR with the activation […]

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Ingenol-3-angelate 1 mg  | >97%

AdipoGen Life Sciences

Specific protein kinase C (PKC) activator. Selective activator of PKC isoforms, like PKCtheta in T cells. Antiproliferative and proapoptotic (necrotic). Immunostimulant. Chemotherapeutic. Anticancer compound. Efficacious agent against actinic kerastosis. Antileukemic.

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Ingenol-3-angelate 5 mg  | >97%

AdipoGen Life Sciences

Specific protein kinase C (PKC) activator. Selective activator of PKC isoforms, like PKCtheta in T cells. Antiproliferative and proapoptotic (necrotic). Immunostimulant. Chemotherapeutic. Anticancer compound. Efficacious agent against actinic kerastosis. Antileukemic.

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Ingenol-5,20-acetonide 1 mg  | >95%

AdipoGen Life Sciences

Intermediate and starting material for the synthesis and preparation of ingenol 3-ester derivatives. For use in chemical synthesis see references. Has improved shelf life compared to ingenol.

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Ingenol-5,20-acetonide 5 mg  | >95%

AdipoGen Life Sciences

Intermediate and starting material for the synthesis and preparation of ingenol 3-ester derivatives. For use in chemical synthesis see references. Has improved shelf life compared to ingenol.

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Ionomycin . calcium salt 1 mg  | >98%

AdipoGen Life Sciences

Antibiotic. Potent and highly selective Ca2+ ionophore. Commonly used to modify intracellular calcium levels to study calcium transport across biological membranes and to calibrate fluorescent Ca2+ indicators. Ionomycin also transports Pb2+ and some other divalent cations, as well as several lanthanide series trivalent cations at efficiencies that are greater than or equal to those for […]

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Ionomycin . calcium salt 5 mg  | >98%

AdipoGen Life Sciences

Antibiotic. Potent and highly selective Ca2+ ionophore. Commonly used to modify intracellular calcium levels to study calcium transport across biological membranes and to calibrate fluorescent Ca2+ indicators. Ionomycin also transports Pb2+ and some other divalent cations, as well as several lanthanide series trivalent cations at efficiencies that are greater than or equal to those for […]

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Ionomycin (free acid) 1 mg  | >98%

AdipoGen Life Sciences

Antibiotic. Potent and highly selective Ca2+ ionophore. Commonly used to modify intracellular calcium levels to study calcium transport across biological membranes and to calibrate fluorescent Ca2+ indicators. Ionomycin also transports Pb2+ and some other divalent cations, as well as several lanthanide series trivalent cations at efficiencies that are greater than or equal to those for […]

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Ionomycin (free acid) 5 mg  | >98%

AdipoGen Life Sciences

Antibiotic. Potent and highly selective Ca2+ ionophore. Commonly used to modify intracellular calcium levels to study calcium transport across biological membranes and to calibrate fluorescent Ca2+ indicators. Ionomycin also transports Pb2+ and some other divalent cations, as well as several lanthanide series trivalent cations at efficiencies that are greater than or equal to those for […]

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IPB 250 mg  | >90%

AdipoGen Life Sciences

4-[3-(4-iodophenyl)-2-(2,4-dinitrophenyl)-2H-5-tetrazolio]-1,3-benzenedisulfonate sodium salt (IPB) have found application in clinical assays and cell proliferation assays that are based on a spectrophotometric measurement of dehydrogenase activities of cells. Disulfonated tetrazolium salt IPB, that produces a highly water-soluble formazan dye that proved to be extremely useful as a cell-viability indicator. IPB is reduced by reduced nicotinamide adenine dinucleotide […]

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IPB 250 mg  | >90%

AdipoGen Life Sciences

4-[3-(4-iodophenyl)-2-(2,4-dinitrophenyl)-2H-5-tetrazolio]-1,3-benzenedisulfonate sodium salt (IPB) have found application in clinical assays and cell proliferation assays that are based on a spectrophotometric measurement of dehydrogenase activities of cells. Disulfonated tetrazolium salt IPB, that produces a highly water-soluble formazan dye that proved to be extremely useful as a cell-viability indicator. IPB is reduced by reduced nicotinamide adenine dinucleotide […]

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IPB 1 g  | >90%

AdipoGen Life Sciences

4-[3-(4-iodophenyl)-2-(2,4-dinitrophenyl)-2H-5-tetrazolio]-1,3-benzenedisulfonate sodium salt (IPB) have found application in clinical assays and cell proliferation assays that are based on a spectrophotometric measurement of dehydrogenase activities of cells. Disulfonated tetrazolium salt IPB, that produces a highly water-soluble formazan dye that proved to be extremely useful as a cell-viability indicator. IPB is reduced by reduced nicotinamide adenine dinucleotide […]

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IPTG (animal-free, dioxane-free) 1 g  | >99%

AdipoGen Life Sciences

Molecular biology reagent. beta-Galactosidase activity inducer in several bacteria, by binding and inhibiting the lac repressor. Used in gene cloning together with X-Gal (Prod. No. AG-CC1-0003), in a technique called blue/white screening. Distinguishes between recombinant and non-recombinant plasmids carrying the beta-galactosidase gene. Plant origin, contains no animal-derived contaminants. Stimulates beta-galactosidase in cellular systems in which […]

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IPTG (animal-free, dioxane-free) 5 g  | >99%

AdipoGen Life Sciences

Molecular biology reagent. beta-Galactosidase activity inducer in several bacteria, by binding and inhibiting the lac repressor. Used in gene cloning together with X-Gal (Prod. No. AG-CC1-0003), in a technique called blue/white screening. Distinguishes between recombinant and non-recombinant plasmids carrying the beta-galactosidase gene. Plant origin, contains no animal-derived contaminants. Stimulates beta-galactosidase in cellular systems in which […]

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IPTG (animal-free, dioxane-free) 25 g  | >99%

AdipoGen Life Sciences

Molecular biology reagent. beta-Galactosidase activity inducer in several bacteria, by binding and inhibiting the lac repressor. Used in gene cloning together with X-Gal (Prod. No. AG-CC1-0003), in a technique called blue/white screening. Distinguishes between recombinant and non-recombinant plasmids carrying the beta-galactosidase gene. Plant origin, contains no animal-derived contaminants. Stimulates beta-galactosidase in cellular systems in which […]

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Iromycin A 500 µg  | >98%

AdipoGen Life Sciences

Pyridone metabolite. Nitric oxide synthase (NOS) inhibitor, showing selectivity for eNOS (NOS III) versus nNOS (NOS I). Thaxtomine biosynthesis inhibitor. Mitochondrial electron transport chain inhibitor.

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Iromycin A 1 mg  | >98%

AdipoGen Life Sciences

Pyridone metabolite. Nitric oxide synthase (NOS) inhibitor, showing selectivity for eNOS (NOS III) versus nNOS (NOS I). Thaxtomine biosynthesis inhibitor. Mitochondrial electron transport chain inhibitor.

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Iromycin A 5 mg  | >98%

AdipoGen Life Sciences

Pyridone metabolite. Nitric oxide synthase (NOS) inhibitor, showing selectivity for eNOS (NOS III) versus nNOS (NOS I). Thaxtomine biosynthesis inhibitor. Mitochondrial electron transport chain inhibitor.

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Isoliquiritigenin 10 mg  | >97%

AdipoGen Life Sciences

Anticancer. Apoptosis inducer and cell proliferation inhibitor. Autophagy inducer. Anti-angiogenic. VEGF/VEGFR-2 signaling inhibitor. Antioxidant and antibacterial. AMPK-mediated GSK3beta inhibitor. Anti-inflammatory. Inhibits translocation and activation of NF-kappaB by blocking phosphorylation and subsequent degradation of IkappaBalpha. Downregulates TRIF-dependent signaling pathways of TLRs by inhibiting TBK1 kinase activity. Blocks LPS-induced TLR4/MD2 complex signaling. NLRP3 inflammasome activation inhibitor. Inhibits […]

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Isoliquiritigenin 50 mg  | >97%

AdipoGen Life Sciences

Anticancer. Apoptosis inducer and cell proliferation inhibitor. Autophagy inducer. Anti-angiogenic. VEGF/VEGFR-2 signaling inhibitor. Antioxidant and antibacterial. AMPK-mediated GSK3beta inhibitor. Anti-inflammatory. Inhibits translocation and activation of NF-kappaB by blocking phosphorylation and subsequent degradation of IkappaBalpha. Downregulates TRIF-dependent signaling pathways of TLRs by inhibiting TBK1 kinase activity. Blocks LPS-induced TLR4/MD2 complex signaling. NLRP3 inflammasome activation inhibitor. Inhibits […]

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Isoprothiolane 500 mg  | >98%

AdipoGen Life Sciences

Isoprothiolane is a dithiolane pesticide. Isoprothiolane is commonly used in agriculture as a fungicide and insecticide to control planthoppers and blast disease in rice plants. Shown to regulate mammary epithelial cell growth in vitro by modulation production of cytokines and improving hepatic lipid metabolism in cows. Compound can be used as analytical reference material.

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Isoprothiolane 2.5 g  | >98%

AdipoGen Life Sciences

Isoprothiolane is a dithiolane pesticide. Isoprothiolane is commonly used in agriculture as a fungicide and insecticide to control planthoppers and blast disease in rice plants. Shown to regulate mammary epithelial cell growth in vitro by modulation production of cytokines and improving hepatic lipid metabolism in cows. Compound can be used as analytical reference material.

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Isoxathion 100 mg  | >98%

AdipoGen Life Sciences

Isoxazole organothiophosphate insecticide. Works as an acetylcholine esterase inhibitor. Compound can be used as analytical reference material.

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Isoxathion 500 mg  | >98%

AdipoGen Life Sciences

Isoxazole organothiophosphate insecticide. Works as an acetylcholine esterase inhibitor. Compound can be used as analytical reference material.

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Itaconic acid 1 g  | >99%

AdipoGen Life Sciences

Mammalian antibacterial metabolite. Inhibitor of isocitrate lyase, the key enzyme of the glyoxylate cycle, essential for bacterial growth. Antimicrobial. Antibacterial. Inhibits the growth of bacteria expressing isocitrate lyase. Phosphofructokinase (PFKII) inhibitor. Suppresses glycolysis by decreasing the level of fructose 2,6-bisphosphate, resulting in decreased visceral fat. Might be involved in the regulation of metabolism. One of […]

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Itaconic acid 5 g  | >99%

AdipoGen Life Sciences

Mammalian antibacterial metabolite. Inhibitor of isocitrate lyase, the key enzyme of the glyoxylate cycle, essential for bacterial growth. Antimicrobial. Antibacterial. Inhibits the growth of bacteria expressing isocitrate lyase. Phosphofructokinase (PFKII) inhibitor. Suppresses glycolysis by decreasing the level of fructose 2,6-bisphosphate, resulting in decreased visceral fat. Might be involved in the regulation of metabolism. One of […]

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IWR-1-endo 5 mg  | >98%

AdipoGen Life Sciences

Potent and reversible cell permeable Wnt pathway signaling inhibitor. Inhibits Wnt-induced accumulation of beta-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, CK1 and GSK-3beta. Stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK-3beta. Tankyrase-1 (TNKS1/PARP5a) and Tankyrase-2 […]

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IWR-1-endo 25 mg  | >98%

AdipoGen Life Sciences

Potent and reversible cell permeable Wnt pathway signaling inhibitor. Inhibits Wnt-induced accumulation of beta-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, CK1 and GSK-3beta. Stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK-3beta. Tankyrase-1 (TNKS1/PARP5a) and Tankyrase-2 […]

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Jak/Src inhibitor 1 . hydrochloride 1 mg  | >97%

AdipoGen Life Sciences

Anticancer compound. Potent antiproliferative agent in vitro and in vivo. Combined inhibitor of pSTAT3 proteins such as JAK, SRC, ABL and class III/V receptor tyrosine kinases (RTK), including FLT3, c-KIT, CSF1-R, PDGFRs and VEGFRs, in nanomolar range.

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