AdipoGen Life Sciences

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AdipoGen Life Sciences develops and manufactures new products for the Life Science Research Market in the key areas of cancer, immunology, inflammation, metabolic syndrome (diabetes, obesity), stem cell biology, and neurodegeneration. The product portfolio consists of antibodies, proteins, ELISA Kits and innovative small molecules. The chemical portfolio includes, rare antibiotics, unique natural products, synthetic kinase modulators, fluorescent probes and much more.

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Concanamycin B (high purity) 100 µg  | >98%

AdipoGen Life Sciences

Antibiotic. Exhibits similar activity as concanamycin A (Prod. No. BVT-0237) and concanamycin C (Prod. No. BVT-0254). Specific vacuolar-type H+-ATPase inhibitor. Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases. Suppresses bone resorption. Inhibits proliferation of mouse splenic lymphocytes. Antifungal and larvicidal.

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Concanamycin B (high purity) 500 µg  | >98%

AdipoGen Life Sciences

Antibiotic. Exhibits similar activity as concanamycin A (Prod. No. BVT-0237) and concanamycin C (Prod. No. BVT-0254). Specific vacuolar-type H+-ATPase inhibitor. Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases. Suppresses bone resorption. Inhibits proliferation of mouse splenic lymphocytes. Antifungal and larvicidal.

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Concanamycin C (high purity) 25 µg  | >98%

AdipoGen Life Sciences

Antibiotic. Vacuolar-type H+-ATPase inhibitor. Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases. Anti-osteoporotic. Antiviral. Immunosuppressive. Antifungal and anti-yeast.

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Concanamycin C (high purity) 100 µg  | >98%

AdipoGen Life Sciences

Antibiotic. Vacuolar-type H+-ATPase inhibitor. Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases. Anti-osteoporotic. Antiviral. Immunosuppressive. Antifungal and anti-yeast.

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Concanamycin C (high purity) 500 µg  | >98%

AdipoGen Life Sciences

Antibiotic. Vacuolar-type H+-ATPase inhibitor. Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases. Anti-osteoporotic. Antiviral. Immunosuppressive. Antifungal and anti-yeast.

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Convulxin 50 µg  | Purity Not Available

AdipoGen Life Sciences

Glycoprotein GPVI receptor agonist. Can be used for studies on platelet receptors. Activates mammalian platelets via binding and clustering of GPVI-receptors under physiological conditions. Occupation and clustering of GPVI activates Src family kinases, phosphorylates Fc receptor gamma-chain and activates p72SYK that is critical for downstream activation of platelets. Causes cardiovascular and respiratory disturbances. Prostaglandins are […]

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Corynesidone A 1 mg  | >98%

AdipoGen Life Sciences

Potent antioxidant. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) scavenger. Anti-cancer and anti-inflammatory compound. Aromatase activity inhibitor. Moderate cytotoxic against selected cancer cell lines.

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Coumarin-6-sulfonyl chloride 50 mg  | >90%

AdipoGen Life Sciences

Derivatizing agent for amines and phenols. Fluorescence is produced in alkaline conditions. Spectral properties: lambdaex 360nm; lambdaem 460nm in alkaline conditions.

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CPM 50 mg  | >95%

AdipoGen Life Sciences

Widely used blue fluorescent thiol-reactive dye (Ex/Em: 384/470nm). This maleimide derivative of coumarin is essentially non-fluorescent until it reacts with thiols, making it possible to quantify thiols without a separation step. Good energy acceptor from tryptophan and a good energy donor to fluorescein. Used to monitor release of thiols and to distinguish proliferating cancer cells […]

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CPM 250 mg  | >95%

AdipoGen Life Sciences

Widely used blue fluorescent thiol-reactive dye (Ex/Em: 384/470nm). This maleimide derivative of coumarin is essentially non-fluorescent until it reacts with thiols, making it possible to quantify thiols without a separation step. Good energy acceptor from tryptophan and a good energy donor to fluorescein. Used to monitor release of thiols and to distinguish proliferating cancer cells […]

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CTPB 1 mg  | >98%

AdipoGen Life Sciences

Potent activator of p300 HAT (histone acetyltransferase) activity, which has an important role in regulation of gene expression. Does not show PCAF (p300/CBP-associated factor) HAT activities. Membrane-impermeable that requires a carrier to pass the membrane barrier of cells.

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CTPB 5 mg  | >98%

AdipoGen Life Sciences

Potent activator of p300 HAT (histone acetyltransferase) activity, which has an important role in regulation of gene expression. Does not show PCAF (p300/CBP-associated factor) HAT activities. Membrane-impermeable that requires a carrier to pass the membrane barrier of cells.

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Cucurbitacin B 1 mg  | >98%

AdipoGen Life Sciences

Microtubule polymerization inhibitor. Disrupts F-actin and induces nucleophosmin/B23 translocation. Immunomodulator with antimicrobial, anti-inflammatory and antitumorigenic properties. Induces apoptosis, autophagy and cell cycle arrest at G2/M phase in a range of cancer cell lines. Shown to inhibit STAT 3 phosphorylation and expression levels and blocks JAK2 activity, as well as the transcriptional activity of HIF1alpha and […]

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Cucurbitacin B 5 mg  | >98%

AdipoGen Life Sciences

Microtubule polymerization inhibitor. Disrupts F-actin and induces nucleophosmin/B23 translocation. Immunomodulator with antimicrobial, anti-inflammatory and antitumorigenic properties. Induces apoptosis, autophagy and cell cycle arrest at G2/M phase in a range of cancer cell lines. Shown to inhibit STAT 3 phosphorylation and expression levels and blocks JAK2 activity, as well as the transcriptional activity of HIF1alpha and […]

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Cucurbitacin B 25 mg  | >98%

AdipoGen Life Sciences

Microtubule polymerization inhibitor. Disrupts F-actin and induces nucleophosmin/B23 translocation. Immunomodulator with antimicrobial, anti-inflammatory and antitumorigenic properties. Induces apoptosis, autophagy and cell cycle arrest at G2/M phase in a range of cancer cell lines. Shown to inhibit STAT 3 phosphorylation and expression levels and blocks JAK2 activity, as well as the transcriptional activity of HIF1alpha and […]

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Cucurbitacin E 1 mg  | >98%

AdipoGen Life Sciences

Potent actin depolymerization inhibitor. Shown to have a different mechanism of action compared to jasplakinolide (Prod. No. AG-CN2-0037), binding to a different site. Binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, stabilizing F-actin without affecting actin polymerization or nucleation. Does not bind to monomeric actin (G-actin). Immunomodulator with anti-inflammatory and […]

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Cucurbitacin E 5 mg  | >98%

AdipoGen Life Sciences

Potent actin depolymerization inhibitor. Shown to have a different mechanism of action compared to jasplakinolide (Prod. No. AG-CN2-0037), binding to a different site. Binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, stabilizing F-actin without affecting actin polymerization or nucleation. Does not bind to monomeric actin (G-actin). Immunomodulator with anti-inflammatory and […]

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Cucurbitacin E 25 mg  | >98%

AdipoGen Life Sciences

Potent actin depolymerization inhibitor. Shown to have a different mechanism of action compared to jasplakinolide (Prod. No. AG-CN2-0037), binding to a different site. Binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, stabilizing F-actin without affecting actin polymerization or nucleation. Does not bind to monomeric actin (G-actin). Immunomodulator with anti-inflammatory and […]

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Curcumin (high purity) 10 mg  | >98%

AdipoGen Life Sciences

Anti-cancer compound. Interferes with multiple cell signaling pathways, including cell cycle (cyclin D1 and cyclin E), apoptosis (activation of caspases and down-regulation of anti-apoptotic gene products), proliferation (HER-2, EGFR and AP-1), survival (PI3K/AKT pathway), invasion (MMP-9 and adhesion molecules), angiogenesis (VEGF), metastasis (CXCR-4) and inflammation (NF-kappaB, TNF, IL-6, IL-1, COX-2 and 5-LOX). Anti-angiogenic. Anti-metastatic. Anti-invasive. […]

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Curcumin (high purity) 50 mg  | >98%

AdipoGen Life Sciences

Anti-cancer compound. Interferes with multiple cell signaling pathways, including cell cycle (cyclin D1 and cyclin E), apoptosis (activation of caspases and down-regulation of anti-apoptotic gene products), proliferation (HER-2, EGFR and AP-1), survival (PI3K/AKT pathway), invasion (MMP-9 and adhesion molecules), angiogenesis (VEGF), metastasis (CXCR-4) and inflammation (NF-kappaB, TNF, IL-6, IL-1, COX-2 and 5-LOX). Anti-angiogenic. Anti-metastatic. Anti-invasive. […]

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Curcumin (high purity) 250 mg  | >98%

AdipoGen Life Sciences

Anti-cancer compound. Interferes with multiple cell signaling pathways, including cell cycle (cyclin D1 and cyclin E), apoptosis (activation of caspases and down-regulation of anti-apoptotic gene products), proliferation (HER-2, EGFR and AP-1), survival (PI3K/AKT pathway), invasion (MMP-9 and adhesion molecules), angiogenesis (VEGF), metastasis (CXCR-4) and inflammation (NF-kappaB, TNF, IL-6, IL-1, COX-2 and 5-LOX). Anti-angiogenic. Anti-metastatic. Anti-invasive. […]

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Curvularin 1 mg  | >95%

AdipoGen Life Sciences

Antibiotic. Antiprotozoal. Antifungal and phytotoxic compound. Anti-inflammatory. TGF-beta signaling inhibitor Anticancer compound. Inhibits expression of inducible nitric oxide synthase (iNOS; NOSII). Cell division inhibitor. Acetylcholinesterase (AChE) inhibitor.

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Curvularin 5 mg  | >95%

AdipoGen Life Sciences

Antibiotic. Antiprotozoal. Antifungal and phytotoxic compound. Anti-inflammatory. TGF-beta signaling inhibitor Anticancer compound. Inhibits expression of inducible nitric oxide synthase (iNOS; NOSII). Cell division inhibitor. Acetylcholinesterase (AChE) inhibitor.

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CX-4945 . hydrochloride [Silmitasertib . HCl] 1 mg  | >98%

AdipoGen Life Sciences

Orally active, potent and selective ATP-competitive inhibitor of the protein kinase CK2 (IC50=1nM). Anticancer compound. Inhibits proliferation in a panel of cancer cell lines that overexpress CK2. Inhibited migration, blocks survival and induces apoptosis in cancer stem cells, glioblastomas and leukemia cells. Shown to decrease the glucose metabolism in cancer cells. Potent inhibitor of Cdc2-like […]

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CX-4945 . hydrochloride [Silmitasertib . HCl] 5 mg  | >98%

AdipoGen Life Sciences

Orally active, potent and selective ATP-competitive inhibitor of the protein kinase CK2 (IC50=1nM). Anticancer compound. Inhibits proliferation in a panel of cancer cell lines that overexpress CK2. Inhibited migration, blocks survival and induces apoptosis in cancer stem cells, glioblastomas and leukemia cells. Shown to decrease the glucose metabolism in cancer cells. Potent inhibitor of Cdc2-like […]

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CX-4945 . hydrochloride [Silmitasertib . HCl] 25 mg  | >98%

AdipoGen Life Sciences

Orally active, potent and selective ATP-competitive inhibitor of the protein kinase CK2 (IC50=1nM). Anticancer compound. Inhibits proliferation in a panel of cancer cell lines that overexpress CK2. Inhibited migration, blocks survival and induces apoptosis in cancer stem cells, glioblastomas and leukemia cells. Shown to decrease the glucose metabolism in cancer cells. Potent inhibitor of Cdc2-like […]

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Cy3 N-succinimdyl ester 1 mg  | >98%

AdipoGen Life Sciences

Bright, orange-fluorescent water-soluble dye that can be excited using the 532nm laser line and visualized with TRITC (tetramethylrhodamine) filter sets. Reactive dye for the labeling of amino-groups in peptides, proteins and oligonucleotides, commonly used for imaging, flow cytometry and genomic applications. It is also the basis for the classic lipophilic tracer DiI and its variants. […]

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Cy3 N-succinimdyl ester 5 mg  | >98%

AdipoGen Life Sciences

Bright, orange-fluorescent water-soluble dye that can be excited using the 532nm laser line and visualized with TRITC (tetramethylrhodamine) filter sets. Reactive dye for the labeling of amino-groups in peptides, proteins and oligonucleotides, commonly used for imaging, flow cytometry and genomic applications. It is also the basis for the classic lipophilic tracer DiI and its variants. […]

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Cy3 N-succinimdyl ester 25 mg  | >98%

AdipoGen Life Sciences

Bright, orange-fluorescent water-soluble dye that can be excited using the 532nm laser line and visualized with TRITC (tetramethylrhodamine) filter sets. Reactive dye for the labeling of amino-groups in peptides, proteins and oligonucleotides, commonly used for imaging, flow cytometry and genomic applications. It is also the basis for the classic lipophilic tracer DiI and its variants. […]

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Cy5 N-succinimdyl ester 1 mg  | >98%

AdipoGen Life Sciences

Bright, far-red fluorescent water-soluble dye ideally suited for the 633nm or 647nm laser line. A significant advantage of using long wavelength dyes over other fluorophores is the low autofluorescence of biological specimens in this region of the spectrum. Reactive dye for the labeling of amino-groups in peptides, proteins and oligonucleotides, commonly used for imaging, flow […]

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Cy5 N-succinimdyl ester 5 mg  | >98%

AdipoGen Life Sciences

Bright, far-red fluorescent water-soluble dye ideally suited for the 633nm or 647nm laser line. A significant advantage of using long wavelength dyes over other fluorophores is the low autofluorescence of biological specimens in this region of the spectrum. Reactive dye for the labeling of amino-groups in peptides, proteins and oligonucleotides, commonly used for imaging, flow […]

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Cy5 N-succinimdyl ester 25 mg  | >98%

AdipoGen Life Sciences

Bright, far-red fluorescent water-soluble dye ideally suited for the 633nm or 647nm laser line. A significant advantage of using long wavelength dyes over other fluorophores is the low autofluorescence of biological specimens in this region of the spectrum. Reactive dye for the labeling of amino-groups in peptides, proteins and oligonucleotides, commonly used for imaging, flow […]

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Cyclopamine 1 mg  | >98%

AdipoGen Life Sciences

Cell permeable steroidal alkaloid. Specific sonic hedgehog (Shh) signaling pathway inhibitor. Directly interacts/inhibits Smo (smoothened). Teratogenic and antitumor compound. Inhibits tumor cell growth and progression. Shows selective activity against Shh-dependent tumors. Blocks abnormal cell growth associated with oncogenic mutations of Ptch and Smo in fibroblasts. Arrests cell cycle at G0/G1. Apoptosis inducer.

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Cyclopamine 5 mg  | >98%

AdipoGen Life Sciences

Cell permeable steroidal alkaloid. Specific sonic hedgehog (Shh) signaling pathway inhibitor. Directly interacts/inhibits Smo (smoothened). Teratogenic and antitumor compound. Inhibits tumor cell growth and progression. Shows selective activity against Shh-dependent tumors. Blocks abnormal cell growth associated with oncogenic mutations of Ptch and Smo in fibroblasts. Arrests cell cycle at G0/G1. Apoptosis inducer.

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Cyclosporin A 100 mg  | >98%

AdipoGen Life Sciences

Potent immunosuppressant (same as FK-506 (Prod. No. AG-CN2-0047) and rapamycin (Prod. No. AG-CN2-0025)). Forms a complex with cyclophilin. Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B (PP2B; calcineurin). Prevents the dephosphorylation of nuclear factor of activated T cells (NFAT) transcription factor, leading to disruption of T cell activation. Suppresses proliferation of cytotoxic T cells […]

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