Clearsynth

Clearsynth is a technology based, research driven enterprise with the World's Largest Inventory of Reference Standards & Research Chemicals. We aim to enable the research community in accelerated discovery via synthesis of complex and difficult to make compounds. We specialize in Innovative Organic chemistry and synthesis of Unique Complex Molecules, Stable Isotope Labelled compounds, Metabolites, Impurities, Glucuronides, Chiral Compounds, Conjugate Impurities, and Radioactive Labelled Compounds. We also undertake synthesis of complex Molecules or "Difficult to Synthesize" compounds/Intermediates. We have a strong commitment towards improving our quality systems, to deliver products that meet and exceed the needs of our customers and regulatory body mandates.

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(1S,3S,4R)-tert-butyl 3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate 500 g  | >98%

Clearsynth

Impurity in commercial preparations of Ledipasvir.

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(1S,3S,4R)-tert-butyl 3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate

(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide hydrochloride 500 g  | >98%

Clearsynth

Intermediate of Saxagliptin

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(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide hydrochloride

(1S,3S,5S)-3-(Aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester 500 g  | >98%

Clearsynth

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(1S,3S,5S)-3-(Aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester

(1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride 500 g  | >98%

Clearsynth

Abacavir intermediate.

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(1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride

(1S,4R)-4-Amino-2-cyclopentene-1-methanol 500 g  | >98%

Clearsynth

(1S,4R)-4-Amino-2-cyclopentene-1-methanol, is an intermediate for the synthesis of Abacavir ; antiviral therapeutic nucleoside analog.

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(1S,4R)-4-Amino-2-cyclopentene-1-methanol

(1S,4R)-cis-4-Amino-2-cyclopentene-1-methanol D-Tartrate 500 g  | >98%

Clearsynth

(1S,4R)-cis-4-Amino-2-cyclopentene-1-methanol is an Abacavir intermediate; antiviral therapeutic nucleoside analog.

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(1S,4R)-cis-4-Amino-2-cyclopentene-1-methanol D-Tartrate

(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane 500 g  | >98%

Clearsynth

Fine Chemical

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(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane

(1S)-(+)-(10-Camphorsulfonyl)oxaziridine 500 g  | >98%

Clearsynth

Intermediates

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(1S)-(+)-(10-Camphorsulfonyl)oxaziridine

(1S)-(+)-10-Camphorsulfonic Acid 500 g  | >98%

Clearsynth

Catalysts

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(1S)-(+)-10-Camphorsulfonic Acid

(1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline 500 g  | >98%

Clearsynth

Solifenacin intermediate.

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(1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline

(1S)-4,5-Dimethoxy-1-(Methylaminomethyl)-Benzocyclobutane Hydrochloride 500 g  | >98%

Clearsynth

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(1S)-4,5-Dimethoxy-1-(Methylaminomethyl)-Benzocyclobutane Hydrochloride

(2-Carboxyethyl)triphenylphosphonium bromide 500 g  | >98%

Clearsynth

Building Blocks

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(2-Carboxyethyl)triphenylphosphonium bromide

(2-Chloroethyl) Phosphonic Acid 500 g  | >98%

Clearsynth

Fine Chemical

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(2-Chloroethyl) Phosphonic Acid

(2-Isopropyl-4-(methylaminomethyl)thiazole) 500 g  | >98%

Clearsynth

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(2-Isopropyl-4-(methylaminomethyl)thiazole)

(22R)-Budesonide 500 g  | >98%

Clearsynth

Budesonide epimer R. Budesonide 22R epimer is more active than 22S epimer. Used as an antiinflammatory agent.

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(22R)-Budesonide

(22S,23S)-28-Homo Brassinolide 500 g  | >98%

Clearsynth

Intermediates

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(22S,23S)-28-Homo Brassinolide

(22S)-Budesonide 500 g  | >98%

Clearsynth

Budesonide epimer S. Budesonide 22R epimer is more active than 22S epimer.

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(22S)-Budesonide

(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol 500 g  | >98%

Clearsynth

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(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol

(2R,3S)-3-(tert-Butoxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutane 500 g  | >98%

Clearsynth

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(2R,3S)-3-(tert-Butoxycarbonylamino)-1-chloro-2-hydroxy-4-phenylbutane

(2R,3S)-N-Benzoyl-3-phenyl Isoserine Ethyl Ester 500 g  | >98%

Clearsynth

Intermediates

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(2R,3S)-N-Benzoyl-3-phenyl Isoserine Ethyl Ester

(2R,5R)-5-Hydroxy-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester 500 g  | >98%

Clearsynth

Lamivudine (L172500) intermediate.

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(2R,5R)-5-Hydroxy-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester

(2R)-(2-chloromethyl)oxirane 500 g  | >98%

Clearsynth

R-enantiomer of Epichlorohydrin, an important industrial chemical, is a bifunctional alkylating agent with the potential to form DNA cross-links. It is used as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishe

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(2R)-(2-chloromethyl)oxirane

(2R)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-4-(phenylmethyl)-3-morpholinone 500 g  | >98%

Clearsynth

(2R)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-4-(phenylmethyl)-3-morpholinone, is the key 3-(4-Fluorophenyl)morpholine moiety used in the synthesis of NK1 receptor antagonist Aprepitant .

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(2R)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-4-(phenylmethyl)-3-morpholinone

(2R)-5,7-Dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one 500 g  | >98%

Clearsynth

Fine Chemical

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(2R)-5,7-Dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one

(2S,3R)-ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,3-dihydroxy-2-methylpropanoate 500 g  | >98%

Clearsynth

Fine Chemical

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(2S,3R)-ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,3-dihydroxy-2-methylpropanoate

(2S,3S)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol 500 g  | >98%

Clearsynth

Impurity in commercial preparations of Efinaconazole.

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(2S,3S)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol

(2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic Acid 1-Benzyl Ester 500 g  | >98%

Clearsynth

A competitive inhibitor of porcine kidney prolidase.

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(2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic Acid 1-Benzyl Ester

(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile 500 g  | >98%

Clearsynth

(2S)-1-(2-Chloroacetyl)-2-9-pyrrolidinecarbonitrile is a key intermediate for dipeptidyl peptidase IV inhibitor Vildagliptin .

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(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile

(2S)-2-Amino-5-(benzyloxy)-5-oxopentanoic acid 500 g  | >98%

Clearsynth

Fine Chemical

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(2S)-2-Amino-5-(benzyloxy)-5-oxopentanoic acid

(2S)-2-Amino-5-tert-butoxy-5-oxopentanoic acid 500 g  | >98%

Clearsynth

Fine Chemical

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(2S)-2-Amino-5-tert-butoxy-5-oxopentanoic acid

(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valine 500 g  | >98%

Clearsynth

Fine Chemical

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(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valine

(3-α,5-β,12-α)-3,12-dihydroxy-Chol-9(11)-en-24-oic acid 500 g  | >98%

Clearsynth

Impurity in commercial preparations of Cholic Acid.

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(3-α,5-β,12-α)-3,12-dihydroxy-Chol-9(11)-en-24-oic acid

(3-α,5-β,12-β)-3,12-dihydroxy-Cholan-24-oic acid 500 g  | >98%

Clearsynth

Impurity in commercial preparations of Cholic acid.

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(3-α,5-β,12-β)-3,12-dihydroxy-Cholan-24-oic acid

(3-Benzoylphenyl)acetonitrile 500 g  | >98%

Clearsynth

Intermediates

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(3-Benzoylphenyl)acetonitrile

(3-Bromopropyl)triphenylphosphonium Bromide 500 g  | >98%

Clearsynth

Fine Chemical

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(3-Bromopropyl)triphenylphosphonium Bromide

(3-Carboxypropyl)triphenylphosphonium Bromide 500 g  | >98%

Clearsynth

(3-Carboxypropyl)triphenylphosphonium Bromide is a reagent used in the preparation of sphingosine 1-phosphate-1 receptor antagonists. Also used in the synthesis of mitochondrial vitamin E metabolites and other mitochondrial targets in the study of mitochodrial functions. Also used in the preparation of benzosuberene analogs that inhibit tubulin assembly and demonstrate cytotoxicity.

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(3-Carboxypropyl)triphenylphosphonium Bromide

(3-Ethyl-1-adamantyl)amine hydrochloride 500 g  | >98%

Clearsynth

Fine Chemical

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(3-Ethyl-1-adamantyl)amine hydrochloride

(3-Methyl-1-adamantyl)amine hydrochloride 500 g  | >98%

Clearsynth

Fine Chemical

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(3-Methyl-1-adamantyl)amine hydrochloride

(3β)-7-Dehydro Cholesterol 500 g  | >98%

Clearsynth

Impurities

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(3β)-7-Dehydro Cholesterol

(3β)-Allopregnanolone Sulfate Sodium Salt 500 g  | >98%

Clearsynth

(3β)-Allopregnanolone Sulfate is the sulfate conjugate of (3β)-Allopregnanolone, a metabolite of progesterone and a potent inhibitory modulator of GABAA receptors.

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(3β)-Allopregnanolone Sulfate Sodium Salt

(3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d]dioxol-4-ol 500 g  | >98%

Clearsynth

(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol was used to preapare AZD6140 as an orally active reversible P2Y12 receptor antagonist for prevention of thrombosis.

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(3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d]dioxol-4-ol

(3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione 500 g  | >98%

Clearsynth

Intermediate of Lurasidone.

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(3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione

(3R, 5R)-Pitavastatin Calcium 500 g  | >98%

Clearsynth

Impurities

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(3R, 5R)-Pitavastatin Calcium

(3R,4S)-1-(4-Fluorophenyl)-2-oxo-4-[4-(benzyloxy)phenyl]-3-azetidinepropanoic acid 500 g  | >98%

Clearsynth

Intermediate of Ezetimibe

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(3R,4S)-1-(4-Fluorophenyl)-2-oxo-4-[4-(benzyloxy)phenyl]-3-azetidinepropanoic acid

(3R,5R)-6-Cyano-3,5-dihydroxy-hexanoic Acid tert-Butyl Ester 500 g  | >98%

Clearsynth

Intermediate in the production of Atorvastatin.

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(3R,5R)-6-Cyano-3,5-dihydroxy-hexanoic Acid tert-Butyl Ester

(3R,5R)-Rosuvastatin Calcium 500 g  | >98%

Clearsynth

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(3R,5R)-Rosuvastatin Calcium

(3R,8S,9S,12R)-Atazanavir 500 g  | >98%

Clearsynth

(3R,8S,9S,12R)-Atazanavir is an impurity of Atazanavir . Atazanavir impurity 2. ;Impurity in commercial preparations of Atazanavir

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(3R,8S,9S,12R)-Atazanavir

(3R,8S,9S,12S) Atazanavir 500 g  | >98%

Clearsynth

An isomer of Atazanavir.

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(3R,8S,9S,12S) Atazanavir

(3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one 500 g  | >98%

Clearsynth

Fine Chemical

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(3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one

(3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester 500 g  | >98%

Clearsynth

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(3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester