Fumagillin (high purity)
Meroterpenoid antibiotic. Anticancer, antimicrobial, antimalarial and amoebicidal compound. Potent, selective and covalent inhibitor of methionine aminopeptidase-2 (MetAP2). Anti-angiogenic by impairing the growth of endothelial cells and altering gene expression. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo. Suppresses the HIV-1 infection of human macrophages through the inhibition of HIV-1 viral protein R (Vpr) activity. Inhibits neovascularization and might be useful in non-tumor diseases such as diabetic retinopathy, arthritis and psoriasis, which involve neovascularisation processes. Reduces diet-induced adipose tissue formation in mice, independent of its effects on angiogenesis.
Catalog Number | BVT-0424-M005 |
Alternative Name(s) | Amebacilin; Fugilin; Fumidil; Fumadil B; NSC9168; U5762 |
Research Area | Antibiotic, Cancer, Inflammation, Natural Products |
Molecular Formula | C26H34O7 |
CAS# | 23110-15-8 |
Purity | >98% |
Inchi | InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23?,24-,25+,26+/m1/s1 |
Inchi Key | NGGMYCMLYOUNGM-IWMBURASSA-N |
SMILES | [H][C@@]1([C@H](OC)[C@@H](CC[C@]11CO1)OC(=O)C=CC=CC=CC=CC(O)=O)[C@@]1(C)O[C@@H]1CC=C(C)C |
Size | 5 mg |
Supplier Page | http://www.adipogen.com/bvt-0424/fumagillin-high-purity.html |