MBIMPH F-Analog 1 . hydrochloride
Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =3nM). Displays high selectivity over all other HDACs (IC50=0.03-20µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (AG-CR1-3900). HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
| Catalog Number | AG-CR1-3908-M001 |
| Alternative Name(s) | MBIMPH Fluorinated Analog 1; 3-Fluoro-N-hydroxy-4-((2-methyl-1H-benzo[d]imidazol-1-yl)methyl)benzamide |
| Research Area | Biochemicals, Cancer, Inflammation, Neurodegenerative Disease |
| Molecular Formula | C16H14FN3O2 . HCl |
| Purity | >95% |
| Inchi | InChI=1S/C16H14FN3O2.ClH/c1-10-18-14-4-2-3-5-15(14)20(10)9-12-7-6-11(8-13(12)17)16(21)19-22;/h2-8,22H,9H2,1H3,(H,19,21);1H |
| Inchi Key | NWMOSGPUNITEFR-UHFFFAOYSA-N |
| SMILES | Cl.CC1=NC2=C(C=CC=C2)N1CC1=C(F)C=C(C=C1)C(=O)NO |
| Size | 1 mg |
| Supplier Page | http://www.adipogen.com/ag-cr1-3908/mbimph-f-analog-1-hydrochloride.html |