Glyburide (USP)
Antidiabetic compound. Binds to and activates the ATP-sensitive potassium channels (KATP) inhibitory regulatory subunit sulfonylurea receptor 1 (SUR1). Causes cell membrane depolarization and opening of voltage-dependent calcium channel. Increases intracellular calcium and stimulates insulin secretion in beta cells NLRP3 inflammasome inhibitor. Broad-spectrum ATP-binding cassette (ABC) transporter inhibitor. Shown to have anti-leishmanial activity. Potential inhibitor of collagenases.
| Catalog Number | AG-CR1-3613-G001 |
| Alternative Name(s) | Diabeta; Glibenclamide |
| Research Area | Biochemicals, Inflammasomes, Inflammation, Metabolism, Obesity |
| Molecular Formula | C23H28ClN3O5S |
| CAS# | 10238-21-8 |
| Purity | >98% |
| Inchi | InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29) |
| Inchi Key | ZNNLBTZKUZBEKO-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C(Cl)C=C1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1 |
| Size | 1 g |
| Supplier Page | http://www.adipogen.com/ag-cr1-3613/glyburide-usp.html |