IHR-1
Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane impermeable Smoothened (Smo) antagonist. Acts on extracellularly exposed Smo only. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.
| Catalog Number | AG-CR1-3526-M001 |
| Alternative Name(s) | Inhibitor of Hedgehog Response 1; N,N'-1,4-Phenylene bis[2,5-dichloro-benzamide |
| Research Area | Biochemicals, Cancer |
| Molecular Formula | C20H12Cl4N2O2 |
| CAS# | 548779-60-8 |
| Purity | >98% |
| Inchi | InChI=1S/C20H12Cl4N2O2/c21-11-1-7-17(23)15(9-11)19(27)25-13-3-5-14(6-4-13)26-20(28)16-10-12(22)2-8-18(16)24/h1-10H,(H,25,27)(H,26,28) |
| Inchi Key | VCLHHRGZKNUOAQ-UHFFFAOYSA-N |
| SMILES | ClC1=CC(C(=O)NC2=CC=C(NC(=O)C3=CC(Cl)=CC=C3Cl)C=C2)=C(Cl)C=C1 |
| Size | 1 mg |
| Supplier Page | http://www.adipogen.com/ag-cr1-3526/ihr-1.html |