SMI-4a
Selective inhibitor of Pim-1 and Pim-2 protein kinases. Inducer of G1 phase cell cycle arrest. Inducer of p27Kip1. Inducer of apoptosis through the mitochondrial pathway. Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway. Downregulates c-myc. Inhibitor of PRAS40 phosphorylation and mTOR activity. Potential anti-cancer compound. Blocks prostate cancer growth.
| Catalog Number | AG-CR1-3503-M005 |
| Alternative Name(s) | (5E/Z)-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione |
| Research Area | Apoptosis, Biochemicals, Cancer, Cell Death, Immunology |
| Molecular Formula | C11H6F3NO2S |
| CAS# | 327033-36-3 |
| Purity | >95% |
| Inchi | InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5- |
| Inchi Key | NGJLOFCOEOHFKQ-YVMONPNESA-N |
| SMILES | FC(F)(F)C1=CC(C=C2/SC(=O)NC2=O)=CC=C1 |
| Size | 5 mg |
| Supplier Page | http://www.adipogen.com/ag-cr1-3503/smi-4a.html |