Bisindolylmaleimide VIII . AcOH [Ro 31-7549]
Selective protein kinase C (PKC) inhibitor. Inhibits proliferation of cultured mouse epidermal keratinocytes. Enhances Fas- and TRAIL-mediated apoptosis. Inhibits T cell-mediated autoimmune diseases. Inhibits stimulation of insulin secretion by glucose. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2).
| Catalog Number | AG-CR1-0114-M001 |
| Alternative Name(s) | Ro 31-7549; BIM VIII |
| Research Area | Apoptosis, Biochemicals, Cancer, Cell Death, Inflammation, Metabolism |
| Molecular Formula | C24H22N4O2 . CH3COOH |
| CAS# | 138516-31-1 |
| Purity | >98% |
| Inchi | InChI=1S/C24H22N4O2.C2H4O2/c1-27-13-17(15-7-2-4-9-19(15)27)21-22(24(30)26-23(21)29)18-14-28(12-6-11-25)20-10-5-3-8-16(18)20;1-2(3)4/h2-5,7-10,13-14H,6,11-12,25H2,1H3,(H,26,29,30);1H3,(H,3,4) |
| Inchi Key | VEOXVBTXROWDAH-UHFFFAOYSA-N |
| SMILES | CC(O)=O.CN1C=C(C2=C1C=CC=C2)C1=C(C(=O)NC1=O)C1=CN(CCCN)C2=C1C=CC=C2 |
| Size | 1 mg |
| Supplier Page | http://www.adipogen.com/ag-cr1-0114/bisindolylmaleimide-viii-acetate.html |