Splitomicin
Potent cell permeable and selective inhibitor of yeast NAD+-dependent histone deacetylase (HDAC) Sir2p. Displays higher activity in vivo than in vitro. Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket. Shown to have diverse effects also in mammalian cells.
| Catalog Number | AG-CR1-0088-M025 |
| Alternative Name(s) | Splitomycin; 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one; 1-Naphthalen propanoic acid |
| Research Area | Biochemicals, Cancer, Immunology, Metabolism |
| Molecular Formula | C13H10O2 |
| CAS# | 5690-03-9 |
| Purity | >98% |
| Inchi | InChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2 |
| Inchi Key | ISFPDBUKMJDAJH-UHFFFAOYSA-N |
| SMILES | O=C1CCC2=C(O1)C=CC1=CC=CC=C21 |
| Size | 25 mg |
| Supplier Page | http://www.adipogen.com/ag-cr1-0088/splitomicin.html |