LY-333,531 . hydrochloride
Isozyme selective inhibitor of protein kinase Cbeta (PKCbeta). PKCbetaI and PKCbetaII isozyme inhibitor. Amelioriates diabetic retinopathy, diabetic peripheral neuropathy and diabetic nephropathy. Anti-cancer and anti-angiogenic compound. Suppresses glucose-induced adhesion of human monocytes to endothelial cells. Suppresses ERK1/2 and Akt phosphorylation.
| Catalog Number | AG-CR1-0087-M005 |
| Alternative Name(s) | Ruboxistaurin |
| Research Area | Biochemicals, Cancer, Inflammation, Metabolism, Neurodegenerative Disease |
| Molecular Formula | C28H28N4O3 . HCl |
| CAS# | 169939-93-9 |
| Purity | >98% |
| Inchi | InChI=1S/C28H28N4O3.ClH/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24;/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34);1H/t18-;/m0./s1 |
| Inchi Key | NYQIEYDJYFVLPO-FERBBOLQSA-N |
| SMILES | Cl.CN(C)C[C@@H]1CCN2C=C(C3=C2C=CC=C3)C2=C(C(=O)NC2=O)C2=CN(CCO1)C1=C2C=CC=C1 |
| Size | 5 mg |
| Supplier Page | http://www.adipogen.com/ag-cr1-0087/ly-333-531-hydrochloride.html |