Compound E
Cell permeable, potent, selective, non-transition state and non-competitive gamma-secretase inhibitor. Notch processing inhibitor. Only weakly affects presenilinase activity.
| Catalog Number | AG-CR1-0081-C250 |
| Alternative Name(s) | gamma-Secretase Inhibitor XXI; (2S)-2-([(3,5-Difluorophenyl)acetyl]amino)-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide |
| Research Area | Biochemicals, Inflammation, Neurobiology, Neurodegenerative Disease |
| Molecular Formula | C27H24F2N4O3 |
| CAS# | 209986-17-4 |
| Purity | >98% |
| Inchi | InChI=1S/C27H24F2N4O3/c1-16(30-23(34)14-17-12-19(28)15-20(29)13-17)26(35)32-25-27(36)33(2)22-11-7-6-10-21(22)24(31-25)18-8-4-3-5-9-18/h3-13,15-16,25H,14H2,1-2H3,(H,30,34)(H,32,35)/t16-,25+/m0/s1 |
| Inchi Key | JNGZXGGOCLZBFB-IVCQMTBJSA-N |
| SMILES | C[C@H](NC(=O)CC1=CC(F)=CC(F)=C1)C(=O)N[C@H]1N=C(C2=CC=CC=C2)C2=C(C=CC=C2)N(C)C1=O |
| Size | 250 µg |
| Supplier Page | http://www.adipogen.com/ag-cr1-0081/compound-e.html |