Bisindolylmaleimide I (free base) [GF-109203X; Gö 6850]
Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competetive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Promotes osteoblastogenesis in human mesenchymal stem cells.
| Catalog Number | AG-CR1-0009-M005 |
| Alternative Name(s) | GF-109203X; Gö 6850; BIM I |
| Research Area | Biochemicals, Cancer, Inflammation, Neurobiology, Stem Cell Research |
| Molecular Formula | C25H24N4O2 |
| CAS# | 133052-90-1 |
| Purity | >98% |
| Inchi | InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31) |
| Inchi Key | QMGUOJYZJKLOLH-UHFFFAOYSA-N |
| SMILES | CN(C)CCCN1C=C(C2=C1C=CC=C2)C1=C(C(=O)NC1=O)C1=CNC2=C1C=CC=C2 |
| Size | 5 mg |
| Supplier Page | http://www.adipogen.com/ag-cr1-0009/bisindolylmaleimide-i.html |