Wedelolactone
Cell permeable, selective and irreversible IKKalpha and beta kinase activity inhibitor. NF-kappaB inhibitor. Blocks phosphorylation and degradation of IkappaBalpha. Antihepatotoxic. 5-Lipoxygenase (5-LOX) inhibitor. Anti-inflammatory. HIV-1 integrase inhibitor. Anticancer and antiproliferative compound. Modulates androgen receptor (AR) activation. Apoptosis inducer via downregulation of PKCepsilon. DNA topoisomerase IIalpha inhibitor. G protein-coupled receptor-35 (GPR35) agonist. Inhibits adipogenic differentiation of mesenchymal stem cells (hAMSCs) through ERK pathway. STAT1 protein dephosphorylation inhibitor. Antifibrotic.
| Catalog Number | AG-CN2-0424-M001 |
| Alternative Name(s) | 7-Methoxy-5,11,12-trihydroxy-coumestan; WDL |
| Research Area | Apoptosis, Biochemicals, Cancer, Cell Death, Inflammation, Natural Products |
| Molecular Formula | C16H10O7 |
| CAS# | 524-12-9 |
| Purity | >98% |
| Inchi | InChI=1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3 |
| Inchi Key | XQDCKJKKMFWXGB-UHFFFAOYSA-N |
| SMILES | COC1=CC(O)=C2C3=C(C4=C(O3)C=C(O)C(O)=C4)C(=O)OC2=C1 |
| Size | 1 mg |
| Supplier Page | http://www.adipogen.com/ag-cn2-0424/wedelolactone.html |