Forskolin
Potent, cell permeable adenylyl cyclase activator. Increases intracellular cAMP levels. Widely used tool to investigate cAMP as a second messenger. Inotropic and antihypertensive. Smooth muscle relaxant/vasodilator. Glucose transporter inhibitor. Platelet aggregation inhibitor. Stimulates lipolysis in fat cells. Non-competitive nicotinic acetylcholine receptors inhibitor. MAP kinase inhibitor. Upregulates mitochondrial uncoupling protein (UCP) mRNA levels in brown adipose tissue. Autophagy inhibitor. Hedgehog signaling inhibitor. Has antiglaucoma potential. Promotes neuronal differentiation of NSCs.
Catalog Number | AG-CN2-0089-M050 |
Alternative Name(s) | Boforsin; Colforsin; Coleonol; NSC 357088; NSC 375489 |
Research Area | Autophagy, Cancer, Immunology, Natural Products, Neurobiology, Stem Cell Research |
Molecular Formula | C22H34O7 |
CAS# | 66428-89-5 and 66575-29-9 |
Purity | >98% |
Inchi | InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1 |
Inchi Key | OHCQJHSOBUTRHG-KGGHGJDLSA-N |
SMILES | [H][C@@]12[C@H](O)[C@H](OC(C)=O)[C@@]3(C)O[C@](C)(CC(=O)[C@]3(O)[C@@]1(C)[C@@H](O)CCC2(C)C)C=C |
Size | 50 mg |
Supplier Page | http://www.adipogen.com/ag-cn2-0089/forskolin.html |