Cyclopamine
Cell permeable steroidal alkaloid. Specific sonic hedgehog (Shh) signaling pathway inhibitor. Directly interacts/inhibits Smo (smoothened). Teratogenic and antitumor compound. Inhibits tumor cell growth and progression. Shows selective activity against Shh-dependent tumors. Blocks abnormal cell growth associated with oncogenic mutations of Ptch and Smo in fibroblasts. Arrests cell cycle at G0/G1. Apoptosis inducer.
| Catalog Number | AG-CN2-0028-M005 |
| Alternative Name(s) | 11-Deoxyjervine; 11-Deoxojervine; HSDB 3505 |
| Research Area | Apoptosis, Cancer, Immunology, Natural Products |
| Molecular Formula | C27H41NO2 |
| CAS# | 4449-51-8 |
| Purity | >98% |
| Inchi | InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1 |
| Inchi Key | QASFUMOKHFSJGL-LAFRSMQTSA-N |
| SMILES | [H][C@@]12C[C@H](C)CN[C@@]1([H])[C@@H](C)[C@@]1(CC[C@]3([H])C(C[C@@]4([H])[C@@]3([H])CC=C3C[C@@H](O)CC[C@]43C)=C1C)O2 |
| Size | 5 mg |
| Supplier Page | http://www.adipogen.com/ag-cn2-0028/cyclopamine.html |