K-252a
Antibiotic. PKC, PKA and PKG inhibitor. Shows neurotropic activity by inducing neurite outgrowth. Highly potent cell permeable CaM kinase and phosphorylase inhibitor. Tyrosine protein kinase inhibitor of the TRK family. Antiproliferative. Apoptosis inducer. Cell cycle arrest inducer. Potential drug for psoriasis treatment.
| Catalog Number | AG-CN2-0019-C100 |
| Alternative Name(s) | SF 2370; Antibiotic K 252a; Antibiotic SF 2370 |
| Research Area | Antibiotic, Apoptosis, Cancer, Cell Death, Inflammation, Natural Products, Neurobiology, Neurodegenerative Disease |
| Molecular Formula | C27H21N3O5 |
| CAS# | 99533-80-9 |
| Purity | >98% |
| Inchi | 1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1 |
| Inchi Key | KOZFSFOOLUUIGY-SOLYNIJKSA-N |
| SMILES | [H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)N1C3=C(C=CC=C3)C3=C4CNC(=O)C4=C4C5=C(C=CC=C5)N2C4=C13 |
| Size | 100 µg |
| Supplier Page | http://www.adipogen.com/ag-cn2-0019/k-252a.html |