JW 55
ADCs Toxins, JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). The JW 55 activity results in stabilization of Axin2 and increased degradation of β-catenin.It inhibits the β-catenin signaling pathway. JW 55 has also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines.
| Trivial name | JW 55 |
| Catalog Number | ADC-P-105 |
| Alternative Name(s) | JW 55 |
| Research Area | ADC research |
| CAS# | 664993-53-7 |
| Purity | >95% |
| Size | 1 mg |
| Supplier Page | https://www.creative-biolabs.com/adc/classify-adc-toxins-6.htm |
| Additional Information | Not fully tested. For research use only. Not for human use. We do not sell to patients. |