Clearsynth

Clearsynth is a technology based, research driven enterprise with the World's Largest Inventory of Reference Standards & Research Chemicals. We aim to enable the research community in accelerated discovery via synthesis of complex and difficult to make compounds. We specialize in Innovative Organic chemistry and synthesis of Unique Complex Molecules, Stable Isotope Labelled compounds, Metabolites, Impurities, Glucuronides, Chiral Compounds, Conjugate Impurities, and Radioactive Labelled Compounds. We also undertake synthesis of complex Molecules or "Difficult to Synthesize" compounds/Intermediates. We have a strong commitment towards improving our quality systems, to deliver products that meet and exceed the needs of our customers and regulatory body mandates.

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(-)-Corey Lactone Diol 500 g  | >98%

Clearsynth

(-)-Corey Lactone Diol is an intermediate of Iloprost and shows inhibitory activity towards lactamase. Iloprost is a synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud’s phenomenon and ischemia.

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(-)-Corey Lactone Diol

(-)-Epigallocatechin Gallate 500 g  | >98%

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(-)-Epigallocatechin Gallate

(-)-Epinephrine 500 g  | >98%

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Building Blocks

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(-)-Epinephrine

(-)-Inosine 500 g  | >98%

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Has neuroprotective properties improving axonal wiring. Has been used to treat stroke patients to restore neural function.

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(-)-Inosine

(-)-N-Deacetyl Colchicine 500 g  | >98%

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An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

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(-)-N-Deacetyl Colchicine

(-)-N-Desmethyl Tramadol Hydrochloride 500 g  | >98%

Clearsynth

Impurities

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(-)-N-Desmethyl Tramadol Hydrochloride

(-)-O- Desmethyl Tramadol 500 g  | >98%

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Metabolites

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(-)-O- Desmethyl Tramadol

(-)-O-Desmethyl Tramadol Hydrochloride 500 g  | >98%

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Metabolites

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(-)-O-Desmethyl Tramadol Hydrochloride

(-)-Tramadol D6 500 g  | >98%

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Stable Isotopes

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(-)-Tramadol D6

(-)-Tramadol Hydrochloride 500 g  | >98%

Clearsynth

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(-)-Tramadol Hydrochloride

(-)-Tranylcypromine Hydrochloride 500 g  | >98%

Clearsynth

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(-)-Tranylcypromine Hydrochloride

((+/-)-3,5-DHPG Hydrochloride 500 g  | >98%

Clearsynth

Fine Chemicals

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((+/-)-3,5-DHPG Hydrochloride

(−)-Norepinephrine 500 g  | >98%

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Fine Chemical

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(−)-Norepinephrine

(+) O Desmethyl Tramadol D6 500 g  | >98%

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Stable Isotopes

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(+) O Desmethyl Tramadol D6

(+)-(R)-Quinuclidin-3-yl [2-(2-benzoylphenyl)ethyl]carbamate 500 g  | >98%

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(+)-(R)-Quinuclidin-3-yl [2-(2-benzoylphenyl)ethyl]carbamate

(+)-β-(2S,3R)-Dihydrotetrabenazine 500 g  | >98%

Clearsynth

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(+)-β-(2S,3R)-Dihydrotetrabenazine

(+)-3-Hydroxy-1,2,3,4-Tetrahydrofuran 500 g  | >98%

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(+)-3-Hydroxy-1,2,3,4-Tetrahydrofuran

(+)-9-O-Desmethyl-α-Dihydrotetrabenazine 500 g  | >98%

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(+)-9-O-Desmethyl-α-Dihydrotetrabenazine

(+)-Catechin hydrate) 500 g  | >98%

Clearsynth

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(+)-Catechin hydrate)

(+)-Dibenzoyl-D-tartaric acid monohydrate 500 g  | >98%

Clearsynth

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(+)-Dibenzoyl-D-tartaric acid monohydrate

(+)-N-Desmethyl Tramadol Hydrochloride 500 g  | >98%

Clearsynth

Impurities

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(+)-N-Desmethyl Tramadol Hydrochloride

(+)-O-Desmethyl Tramadol 500 g  | >98%

Clearsynth

Metabolites

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(+)-O-Desmethyl Tramadol

(+)-Pulegone 500 g  | >98%

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A monoterpene, commonly found in the essential oils of Nepeta cataria (Catnip).

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(+)-Pulegone

(+)-Tramadol 500 g  | >98%

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An analgesic proposed for severe pain

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(+)-Tramadol

(+)-Tramadol D6 500 g  | >98%

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Stable Isotopes

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(+)-Tramadol D6

(+)-Tranylcypromine Hydrochloride 500 g  | >98%

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Antidepressive Agents; Monoamine Oxidase Inhibitors; Anti-Anxiety Agents

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(+)-Tranylcypromine Hydrochloride

(+/-)-2-Pentyl-1,1,1,3,3-d5 Alcohol 500 g  | >98%

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Stable Isotopes

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(+/-)-2-Pentyl-1,1,1,3,3-d5 Alcohol

(+/-)-Anabasine 500 g  | >98%

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A nicotinic receptor agonist

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(+/-)-Anabasine

(+/-)-Metanephrine-alpha,beta,beta D3 Hydrochloride 500 g  | >98%

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Stable Isotopes

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(+/-)-Metanephrine-alpha,beta,beta D3 Hydrochloride

(+/-)-Methionine 500 g  | >98%

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(+/-)-Methionine

(+/-)-trans-1,2-Diaminocyclohexane 500 g  | >98%

Clearsynth

Fine Chemicals

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(+/-)-trans-1,2-Diaminocyclohexane

(14R)-14-Hydroxy Clarithromycin 500 g  | >98%

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Metabolites

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(14R)-14-Hydroxy Clarithromycin

(15R)-Bimatoprost 500 g  | >98%

Clearsynth

Impurity in the commercial production of Bimatoprost .

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(15R)-Bimatoprost

(15R)-Bimatoprost Acid 500 g  | >98%

Clearsynth

(15R)-Bimatoprost Acid is an impurity of the antiglaucoma agent Bimatoprost .(15R)-Bimatoprost Acid is a metabolically stable analog of PGF2a and is a potent agonist for the FP receptor.;Impurity in commercial preparations of Bimatoprost

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(15R)-Bimatoprost Acid

(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine 500 g  | >98%

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(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine

(1R,2R)-1,2-Cyclohexanedimethanol 500 g  | >98%

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Heterocyclic Compounds

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(1R,2R)-1,2-Cyclohexanedimethanol

(1R,2S,5S)-6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic Acid Methyl Ester Hydrochloride 500 g  | >98%

Clearsynth

An azabicyclohexane derivative used in the preparation of hepatitis C virus (HCV) NS3 serine protease inhibitor.

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(1R,2S,5S)-6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic Acid Methyl Ester Hydrochloride

(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine 500 g  | >98%

Clearsynth

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(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine

(1R,3R,4R)-Entecavir 500 g  | >98%

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Impurities

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(1R,3R,4R)-Entecavir

(1R,3R,4S)-tert-butyl 3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate 500 g  | >98%

Clearsynth

Impurity in commercial preparations of Ledipasvir.

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(1R,3R,4S)-tert-butyl 3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate

(1R,3R)-9H-pyrido[3,4-B]indole-3-carboxylic acid, 1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl), methyl ester, hydrochloride 500 g  | >98%

Clearsynth

Impurity in commercial preparations of Tadalafil

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(1R,3R)-9H-pyrido[3,4-B]indole-3-carboxylic acid, 1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl), methyl ester, hydrochloride

(1R,3R)-Methyl-1,2,3,4-tetrahydro-2-chloroacetyl-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate (Chloropretadalafil) 500 g  | >98%

Clearsynth

An intermediate in the synthesis of Tadalafil , which is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.;Impurity in commercial preparations of Tadalafil

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(1R,3R)-Methyl-1,2,3,4-tetrahydro-2-chloroacetyl-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate (Chloropretadalafil)

(1R)-3-(Methylamino)-1-(2-thienyl)-1-propanol 500 g  | >98%

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Intermediates

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(1R)-3-(Methylamino)-1-(2-thienyl)-1-propanol

(1R)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid 500 g  | >98%

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(1R)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

(1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane 500 g  | >98%

Clearsynth

An intermediate of Entecavir.

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(1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane

(1S,2R) Bortezomib 500 g  | >98%

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Impurities

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(1S,2R) Bortezomib

(1S,2R)-2-Amino-1,2-diphenylethanol 500 g  | >98%

Clearsynth

Fine Chemical

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(1S,2R)-2-Amino-1,2-diphenylethanol

(1S,2S)-(+)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol 500 g  | >98%

Clearsynth

Fine Chemical

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(1S,2S)-(+)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol

(1S,2S)-cyclohexane-1,2-diyldimethanol 500 g  | >98%

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(1S,2S)-cyclohexane-1,2-diyldimethanol

(1S,3R,4R) Ledipasvir Intermediate 500 g  | >98%

Clearsynth

Intermediate of Ledipasvir.

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(1S,3R,4R) Ledipasvir Intermediate