An ACh uptake inhibitor and neuromuscular blocking agent

An ACh uptake inhibitor and neuromuscular blocking agent

An ACh uptake inhibitor and neuromuscular blocking agent

An ACh uptake inhibitor and neuromuscular blocking agent

(±)-Vesamicol hydrochloride is an inhibitor of acetylcholine transport (Ki = 2 nM) that blocks the loading of acetylcholine into synaptic vesicles of cholinergic nerve terminals. The inhibition by Vesamicol attenuates acetylcholine neuronal signaling without direct effecys on signaling mechanisms.