(+)-JNJ-A07 is a highly potent inhibitor of Dengue virus (DENV) with an EC50 of 0.1 nM in the DENV-2 strain (16681) in Vero cells. It exhibits antiviral activity by preventing the formation of the viral replication complex through blocking the interaction between two viral proteins, NS3 and NS4B.

(+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction. (+)-JNJ-A07 exerts nanomolar to picomolar activity against a panel of 21 clinical isolates. (+)-JNJ-A07 has a favourable pharmacokinetic profile that results in outstanding efficacy against dengue virus infection in mouse infection models.In Vitro: (+)-JNJ-A07 has a high barrier to resistance […]

(+)-JQ-1 is a potent and selective BET bromodomain inhibitor, IC50 values are 77 nM and 33 nM for inhibiting BRD4 (N-terminal) and BRD4 (C-terminal), respectively.