(2-Benzyloxyphenyl)acetic acid (CAS# 22047-88-7) is a novel O-substituted Hydroxyphenylacetic Acid derivatives, having aldose reductase inhibitory activities. It can also be used for the synthesis of Asperphenamate derivatives, having antitumor activity.

JohnPhos, a bulky phosphine ligand, was employed as catalyst in the following studies: Hydrophenoxylation of unactivated internal alkynes; Microwave-mediated Suzuki-Miyaura cross-coupling of benzylic bromides; Pharmaceutical synthesis of novel imidazo[1,2-a]pyridines, having potent activity against the herpes virus.; Barluenga’s coupling of vinyl bromides with hydrazines; Pd-catalyzed 2,3-diarylation of α,α-disubstituted-3-thiophenemethanols, via cleavage of C-H and C-C bonds. Ligand […]