(−)-WIN 55,212-3 is an aminoalkylindole derivative which acts as a competitive neutral antagonist of the human cannabinoid CB2 receptor and presumably express the CB1 receptor. It also weakly antagonizes the melatonin MT1 and muscarinic M4 receptors but has no effect on several other G protein-coupled receptors.

(-)-Xestospongin C is a potent and reversible inhibitor of IP3 receptor that reguates calcium release. (-)-Xestospongin C has been found to inhibit bradykinin-induced Ca2+ release in PC12 cells and attenuate PHP-induced IL-2 production in Jurkat T cells, but exhibits no effect on ryanodine receptor-mediated Ca2+ release in PC12 cells.

(-)-Zeylenol is a natural product derived from the stems of the Uvaria grandiflora, showing anti-inflammatory, antifeedant and antitumor biological activity, acting by inhibiting the synthesis or release of multiple inflammatory mediators. zezelenol inhibited the root growth of rapeseed and had the potential to induce the apoptosis of human breast cancer MDA-MB231 cells.