ZX703
ZX703 is a proteolysis targeting chimera (PROTAC), that is a degrader of GPX4 through the ubiquitin-proteasome and the autophagy-lysosome with a DC50 of 0.315 µM. It induces the accumulation of lipid reactive oxygen species (ROS), thereby inducing ferroptosis cancer cells.
| Catalog Number | E4652 |
| Molecular Formula | C27H34N6O5 |
| SMILES | COC1=CC2=NC(=NC(=C2C=C1OC)N)N3CCN(C(C3)C(=O)NC(C)(C)C)C(=O)OCC4=CC=CC=C4 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/zx703.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4652-ZX703-chemical-structure-tube.png |