YX0597
YX0597 is a potent and selective CDK9 PROTAC degrader that reduces RNA polymerase II S2 phosphorylation and MCL1 expression in GA0518 and AGS cells. It effectively inhibits GEAC cell growth, including radiation-resistant tumors, and suppresses tumor proliferation, metastasis, and cancer stem cells.
| Catalog Number | E8287 |
| Molecular Formula | C18H16O3 |
| Inchi | InChI=1S/C18H16O3/c1-12(2)21-14-8-9-15-17(10-14)20-11-16(18(15)19)13-6-4-3-5-7-13/h3-12H,1-2H3 |
| Inchi Key | SFBODOKJTYAUCM-UHFFFAOYSA-N |
| SMILES | CC(C)OC1=CC2=C(C=C1)C(=O)C(=CO2)C3=CC=CC=C3 |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/yx0597.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e8287-yx0597-chemical-structure-tube.png |