YW-N-7 TFA
YW-N-7 TFA is a PROTAC that targets the inhibition and degradation of RET with a DC50 of 88 nM. It also exhibits antitumor activity in a KIF5B-RET-driven xenograft mouse model.
Catalog Number | E8288 |
Molecular Formula | C20H16N2O5 |
Inchi | InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1 |
Inchi Key | HAWSQZCWOQZXHI-FQEVSTJZSA-N |
SMILES | CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O |
Size | 1mg |
Supplier Page | http://www.selleckchem.com/products/yw-n-7-tfa.html |
Additional Information | https://file.selleck.cn/downloads/struct/e8288-yw-n-7-tfa-chemical-structure-tube.png |