SPA-10091-HCl

SPA-10091-HCl is a degrader of DOT1L that selectively degrades DOT1L protein through the nuclear ubiquitin-proteasome pathway, thereby suppressing H3K79 methylation in CRPC cells. It also inhibits DOT1L enzymatic activity with an IC50 of 0.87 μM, induces apoptosis, and significantly reduces tumor growth in vivo.

Price Not Available 1mg SPA-10091-HCl Supplier Page

Catalog Number	E8279
Molecular Formula	C27H44O7
Inchi	InChI=1S/C27H44O7/c1-23(2,32)9-8-22(31)26(5,33)21-7-11-27(34)16-12-18(28)17-13-19(29)20(30)14-24(17,3)15(16)6-10-25(21,27)4/h12,15,17,19-22,29-34H,6-11,13-14H2,1-5H3/t15-,17-,19+,20-,21-,22+,24+,25+,2 6+,27+/m0/s1
Inchi Key	NKDFYOWSKOHCCO-YPVLXUMRSA-N
SMILES	CC12CCC3C(=CC(=O)C4C3(CC(C(C4)O)O)C)C1(CCC2C(C)(C(CCC(C)(C)O)O)O)O
Size	1mg
Supplier Page	http://www.selleckchem.com/products/spa-10091-hcl.html
Additional Information	https://file.selleck.cn/downloads/struct/e8279-spa-10091-hcl-chemical-structure-tube.png