LYMTAC-2

LYMTAC-2 is a lysosomal-targeting chimera (LYMTAC) designed to degrade membrane-associated proteins by leveraging lysosomal membrane proteins (LMPs) like RNF152, LAPTM4a, and LAPTM5. It forms a ternary complex with its target protein, such as KRASG12D, and facilitates relocalization to the lysosome, leading to ubiquitin-dependent degradation. It has the potential to study membrane protein regulation and develop strategies to overcome resistance in KRAS-driven signaling pathways.

Price Not Available 1g LYMTAC-2 Supplier Page

Catalog Number	E4738
Molecular Formula	C27H29N5O
Inchi	InChI=1S/C27H29N5O/c28-26-25-24(21-8-4-9-23(14-21)33-17-19-6-2-1-3-7-19)16-32(27(25)30-18-29-26)22-12-20(13-22)15-31-10-5-11-31/h1-4,6-9,14,16,18,20,22H,5,10-13,15,17H2,(H2,28,29,30)/t20-,22+
Inchi Key	AECDBHGVIIRMOI-GRGXKFILSA-N
SMILES	C1CN(C1)CC2CC(C2)N3C=C(C4=C(N=CN=C43)N)C5=CC(=CC=C5)OCC6=CC=CC=C6
Size	1g
Supplier Page	http://www.selleckchem.com/products/lymtac-2.html
Additional Information	https://file.selleck.cn/downloads/struct/E4738-LYMTAC-2-chemical-structure.png