The fibroblast growth factor-4 (FGF-4) gene was identified as HST-1 gene from human stomach cancers and Kaposi’s sarcoma by a NIH3T3 transforming assay. FGF-4 has pleiotropic roles in many cell types and tissues, it is a mitogenic, angiogenic and survival factor, which is involved in cell proliferation and differentiation and in a variety of development processes.