Neutrophil Activating Peptide 2 (NAP-2), also known as Chemokine (C-X-C motif) ligand 7 (CXCL7) and Pro-platelet basic protein (PPBP), is a member of the CXC chemokines. NAP-2 is found in the alpha-granules of human platelets. Nap-2 / PPBP / CXCL7 is released in large amounts from platelets following their activation. Similar to other ELR domain containing CXC chemokines such as IL-8 and the GRO proteins, NAP-2 has been shown to bind CXCR2 and to chemoattract and activate neutrophils. Nap-2 / PPBP / CXCL7 has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Nap-2 is a ligand for CXCR1 and CXCR2, and Nap-2, Nap-2 (73), Nap-2 (74), Nap-2 (1-66), and most potent Nap-2 (1-63).