CCL20, also known as LARC (Liver and Activation-regulated Chemokine) or MIP3A(Macrophage Inflammatory Protein-3), is a small cytokine belonging to the CC chemokine family. CCL20 is Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. The expression of CCL20 is strongly up-regulated by inflammatory signals and down-regulated by the anti-inflammatory cytokine IL-10. CCL20 has been shown to be chemotactic for lymphocytes. This chemokine may Inhibit proliferation of myeloid progenitors in colony formation assays and it may be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. Chemokine CCL2 was shown to play a role in colorectal cancer (CRC) pathogenesis.