Alnuctamab is a bispecific T-cell engager (BiTE) antibody directed against the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; TNFRSF17) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. It demonstrates encouraging antitumor activity in patients with relapsed or refractory multiple myeloma. MW: 192.35 KD.

Emb01 is a tetravalent, bispecific antibody that simultaneously targets the epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (cMET) on tumor cells, preventing receptor activation and inducing receptor endocytosis, which effectively eliminates these targets on tumor cell surfaces. It demonstrates significant anti-tumor activity in patient-derived xenograft (PDX) and cell line-derived xenograft (CDX) models, […]

Izalontamab is a bispecific IgG antibody that targets epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 3 (HER3). It demonstrates significant anti-tumor efficacy and acceptable tolerance in xenograft models of colon cancer, head and neck cancer, and esophageal cancer. MW: 197.22 KD.

Teclistamab is a humanized bispecific IgG4 monoclonal antibody that targets CD3 on T cells and B-cell maturation antigen (BCMA) on multiple myeloma (MM) cells. It triggers a T cell-mediated immune response, leading to the elimination of BCMA-positive cells and exhibits the potential to treat patients with triple-class exposed relapsed/refractory multiple myeloma (R/RMM). MW: 143.66 KD.

Mgd010 is a bispecific dual-affinity retargeting (DART®) molecule that targets both the B cell surface proteins CD32B and CD79B, delivering a co-inhibitory signal to dampen B cell activation. It holds potential for treating autoimmune diseases such as rheumatoid arthritis and other inflammatory conditions. MW: 108.77 KD.

Kn026 is a bispecific antibody that targets human epidermal growth factor receptor 2 (HER2), binding to HER2 domains II and IV. It demonstrates a well-tolerated safety profile and promising anti-tumor efficacy in advanced HER2-positive gastric cancer (GC) and gastroesophageal junction cancer (GEJC). MW: 145.19 KD.

Inbrx-105 is a recombinant, humanized bispecific antibody targeting programmed death-ligand 1 (PD-L1) and 4-1BB (CD137), with potential checkpoint inhibitory, immunostimulating, and antineoplastic activities. By binding to 4-1BB on activated T lymphocytes and PD-L1 on tumor cells, INBRX-105 enhances T-cell co-stimulation and inhibits PD-L1-mediated T-cell inhibition, potentially leading to reduced tumor growth. INBRX-105 exhibits antitumor efficacy […]

Talquetamab is a bispecific humanized monoclonal antibody targeting human CD3 on T cells and the multiple myeloma-associated antigen G protein-coupled receptor family C group 5 member D (GPRC5D) on tumor cells. It redirects T cells to bind and attack GPRC5D-expressing tumor cells, inducing a potent cytotoxic T-lymphocyte (CTL) response. Talquetamab is approved by the U.S. […]

Abt-122 is a dual variable domain immunoglobulin (DVD-Ig) that targets human TNF and IL-17A, with the potential to treat rheumatoid arthritis (RA). MW: 198.74 KD.

Linvoseltamab is a human bispecific T-cell engager (BiTE) antibody that targets the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA) and the CD3 antigen on T lymphocytes. It demonstrates significant antitumor activity and high efficacy in patients with late-stage relapsed/refractory multiple myeloma (RRMM). MW: 145.78 KD.