Atuliflapon (AZD5718) is an oral inhibitor of (FLAP) 5-lipoxygenase activating protein with an IC50 of 2.0 nM. It has the potential to treat coronary artery disease.

FSG67 is an inhibitor of glycerol 3-phosphate acyltransferase (GPAT) with an IC50 of 24 μM. It increases oxidative metabolism in mature adipocytes and blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling.

FSG67 is an inhibitor of glycerol 3-phosphate acyltransferase (GPAT) with an IC50 of 24 μM. It increases oxidative metabolism in mature adipocytes and blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling.

FSG67 is an inhibitor of glycerol 3-phosphate acyltransferase (GPAT) with an IC50 of 24 μM. It increases oxidative metabolism in mature adipocytes and blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling.

GPR84 antagonist 8 is an antagonist of GPR84,which abrogates the enhanced inflammatory response mediated by 6-OAU. It has the potential to reduce the inflammatory responses associated with the activation of the GPR84 receptor.

Chicoric acid is an orally active dicaffeoyltartaric acid with antioxidant, anti-inflammatory, and antidiabetic properties. It induces ROS generation and triggers mitochondria-dependent apoptosis in 3T3-L1 preadipocytes via PI3K/Akt and MAPK pathways. It also enhances glucose uptake and improves insulin resistance.

GPR84 antagonist 8 is an antagonist of GPR84,which abrogates the enhanced inflammatory response mediated by 6-OAU. It has the potential to reduce the inflammatory responses associated with the activation of the GPR84 receptor.

Iberiotoxin TFA(IbTX) is a toxin purified from the scorpion Buthus tamulus. Iberiotoxin is a potent blocker of the large conductance Ca(2+)-activated K+ channel with a Kd of ~1 nM.

Hispidin is a phenolic compound from Phellinus linteus (a medicinal mushroom) and a potent inhibitor of protein kinase Cβ(PKC) with an IC50 of 2 μM, respectively. It also inhibits beta-secretase (BACE1) and prolyl endopeptidase(PE) with IC50 values of 4.9 μM and 16 μM respectively. It exhibits strong anti-oxidant, anti-cancer, anti-diabetic, anti-dementia, anti-inflammatory, anti-apoptotic, and antiviral […]

Hispidin is a phenolic compound from Phellinus linteus (a medicinal mushroom) and a potent inhibitor of protein kinase Cβ(PKC) with an IC50 of 2 μM, respectively. It also inhibits beta-secretase (BACE1) and prolyl endopeptidase(PE) with IC50 values of 4.9 μM and 16 μM respectively. It exhibits strong anti-oxidant, anti-cancer, anti-diabetic, anti-dementia, anti-inflammatory, anti-apoptotic, and antiviral […]