Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1.

Paxilline, an indole alkaloid mycotoxin derived from Penicillium paxilli, potently inhibits the BK channel by exerting its effects through direct channel inhibition. Additionally, Paxilline also functions as an inhibitor of sarco/endoplasmic reticulum Ca2+-stimulated ATPase (SERCA), with IC50 values ranging from 5 μM-50 μM, depending on the SERCA isoform. Paxilline also possesses significant anticonvulsant and neuroprotective […]

Paxilline, an indole alkaloid mycotoxin derived from Penicillium paxilli, potently inhibits the BK channel by exerting its effects through direct channel inhibition. Additionally, Paxilline also functions as an inhibitor of sarco/endoplasmic reticulum Ca2+-stimulated ATPase (SERCA), with IC50 values ranging from 5 μM-50 μM, depending on the SERCA isoform. Paxilline also possesses significant anticonvulsant and neuroprotective […]

KDM5-C70 is an ethyl ester derivative of KDM5-C49 and a potent, cell-permeable and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, leading to genome-wide elevation of H3K4me3 levels.

Braco-19 trihydrochloride(BRAC-O19, BRACO19 3HCl) is a G-quadruplex-stabilizing agent and an inhibitor of telomere/telomerase. It establishes antiviral activity against HIV-1 and anticancer effects by inhibiting telomerase capping and catalytic functions.

Braco-19 trihydrochloride(BRAC-O19, BRACO19 3HCl) is a G-quadruplex-stabilizing agent and an inhibitor of telomere/telomerase. It establishes antiviral activity against HIV-1 and anticancer effects by inhibiting telomerase capping and catalytic functions.

Braco-19 trihydrochloride(BRAC-O19, BRACO19 3HCl) is a G-quadruplex-stabilizing agent and an inhibitor of telomere/telomerase. It establishes antiviral activity against HIV-1 and anticancer effects by inhibiting telomerase capping and catalytic functions.

Imlunestrant(LY3484356) is a potent, orally bioavailable selective estrogen receptor degrader (SERD) that functions as a pure antagonist of estrogen receptor alpha (ERα). It inhibits ER-dependent gene transcription and cell proliferation, resulting in sustained suppression of estrogen-driven growth in ER-positive cells.

Braco-19 trihydrochloride(BRAC-O19, BRACO19 3HCl) is a G-quadruplex-stabilizing agent and an inhibitor of telomere/telomerase. It establishes antiviral activity against HIV-1 and anticancer effects by inhibiting telomerase capping and catalytic functions.

Imlunestrant(LY3484356) is a potent, orally bioavailable selective estrogen receptor degrader (SERD) that functions as a pure antagonist of estrogen receptor alpha (ERα). It inhibits ER-dependent gene transcription and cell proliferation, resulting in sustained suppression of estrogen-driven growth in ER-positive cells.