Elsubrutinib(ABBV-105) is a covalent, irreversible, potent, and highly selective inhibitor of Bruton’s Tyrosine Kinase (BTK), with an IC50 of 0.18 μM for BTK catalytic domain. It specifically inhibits BTK dependent cellular functions, including both BCR and FcγR mediated signaling. It also exhibits significant efficacy in pre-clinical mechanistic models of antibody production, as well as in […]

BMS-509744 is a potent, selective and ATP competitive Itk inhibitor with an IC50 of 19 nM.

Elsubrutinib(ABBV-105) is a covalent, irreversible, potent, and highly selective inhibitor of Bruton’s Tyrosine Kinase (BTK), with an IC50 of 0.18 μM for BTK catalytic domain. It specifically inhibits BTK dependent cellular functions, including both BCR and FcγR mediated signaling. It also exhibits significant efficacy in pre-clinical mechanistic models of antibody production, as well as in […]

AZD8797 (KAND567) is an allosteric, non-competitive, and orally active antagonist of the human receptor CX3CR1. It antagonizes CX3CR1 with a Ki value of 3.9 nM, respectively. It effects G-protein signaling and β-arrestin recruitment.

Elsubrutinib(ABBV-105) is a covalent, irreversible, potent, and highly selective inhibitor of Bruton’s Tyrosine Kinase (BTK), with an IC50 of 0.18 μM for BTK catalytic domain. It specifically inhibits BTK dependent cellular functions, including both BCR and FcγR mediated signaling. It also exhibits significant efficacy in pre-clinical mechanistic models of antibody production, as well as in […]

AZD8797 (KAND567) is an allosteric, non-competitive, and orally active antagonist of the human receptor CX3CR1. It antagonizes CX3CR1 with a Ki value of 3.9 nM, respectively. It effects G-protein signaling and β-arrestin recruitment.

AZD8797 (KAND567) is an allosteric, non-competitive, and orally active antagonist of the human receptor CX3CR1. It antagonizes CX3CR1 with a Ki value of 3.9 nM, respectively. It effects G-protein signaling and β-arrestin recruitment.

AZD8797 (KAND567) is an allosteric, non-competitive, and orally active antagonist of the human receptor CX3CR1. It antagonizes CX3CR1 with a Ki value of 3.9 nM, respectively. It effects G-protein signaling and β-arrestin recruitment.

UNC8153 is a selective degrader of nuclear receptor-binding SET domain-containing 2 (NSD2) with a binding Kd of 24 nM, effectively reducing NSD2 protein levels and the dimethylate lysine 36 of histone 3 (H3K36me2) chromatin mark. Its simple warhead promotes proteasome-dependent degradation of NSD2 via a novel mechanism.

UNC8153 is a selective degrader of nuclear receptor-binding SET domain-containing 2 (NSD2) with a binding Kd of 24 nM, effectively reducing NSD2 protein levels and the dimethylate lysine 36 of histone 3 (H3K36me2) chromatin mark. Its simple warhead promotes proteasome-dependent degradation of NSD2 via a novel mechanism.